SCHEMBL7202213

SCHEMBL7202213

CC(C)Nc1cccnc1N1CCN(C(=O)c2cc3cc(N[S+](C)[O-])ccc3[nH]2)CC1

nearest known ligand 0.75

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
ADRA2A P08913 1/20 0.75
ADORA3 P0DMS8 1/20 0.75
CHRM1 P11229 1/20 0.75
MAOA P21397 1/20 0.75
TBXA2R P21731 1/20 0.75
OPRM1 P35372 1/20 0.75
MDH1 P40925 1/20 0.75
KCNH2 Q12809 1/20 0.75
ABCG2 Q9UNQ0 1/20 0.75
SYK P43405 17/20 0.46
HRH3 Q9Y5N1 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Delavirdine SCHEMBL34420 0.86 ADRA2A (1.00) ADRA2AADORA3CHRM1MAOATBXA2R
Delavirdine SCHEMBL29602259 0.86 ADRA2A (1.00) ADRA2AADORA3CHRM1MAOATBXA2R
Delavirdine SCHEMBL29714124 0.86 ADRA2A (1.00) ADRA2AADORA3CHRM1MAOATBXA2R
Delavirdine SCHEMBL30803764 0.86 ADRA2A (1.00) ADRA2AADORA3CHRM1MAOATBXA2R
SCHEMBL18326508 0.85 ADRA2A (0.75) ADRA2AADORA3CHRM1MAOATBXA2R
Delavirdine SCHEMBL28170537 0.85 ADRA2A (0.98) ADRA2AADORA3CHRM1MAOATBXA2R
Delavirdine SCHEMBL40522 0.85 ADRA2A (0.98) ADRA2AADORA3CHRM1MAOATBXA2R
Delavirdine SCHEMBL29585604 0.85 ADRA2A (0.98) ADRA2AADORA3CHRM1MAOATBXA2R
Delavirdine SCHEMBL3221265 0.85 ADRA2A (0.98) ADRA2AADORA3CHRM1MAOATBXA2R
SCHEMBL8795012 0.85 ADRA2A (0.74) ADRA2AADORA3CHRM1MAOATBXA2R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2016135046-A1 INHIBITORS OF RAF1, MST1, AND PKL1 FOR USE IN THE TREATMENT OF A RETROVIRUS ACADEMISCH MEDISCH CENTRUM (NL) 2016-09-01 WO disclosed
CN-101941990-A The prodrug of the piperidine antiviral agents of piperazine and replacement BRISTOL MYERS SQUIBB CO 2011-01-12 CN disclosed
CN-1953985-B Prodrugs of piperazine and substituted piperidine antiviral drugs BRISTOL MYERS SQUIBB CO 2010-06-09 CN disclosed
CN-1953985-A Prodrugs of piperazine and substituted piperidine antiviral drugs BRISTOL MYERS SQUIBB CO (US) 2007-04-25 CN disclosed
EP-1420745-A2 USE OF R-NSAID COMPOUNDS FOR ANTI-HIV TREATMENT MYRIAD GENETICS, INC. (US) 2004-05-26 EP disclosed
WO-2003013424-A2 USE OF R-NSAID COMPOUNDS FOR ANTI-HIV TREATMENT MYRIAD GENETICS, INC (US) 2003-02-20 WO disclosed