Sugi Predict

Sugi Predict / Compounds / SCHEMBL7203407

SCHEMBL7203407

SCHEMBL7203407

O=c1cc(-c2cccc(Cl)c2)c2cc(C(O)c3ccc(Cl)cc3)cc3c2n1CCC3

nearest known ligand 0.55

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ FNTA P49354 9/20 0.55
▸ FNTB P49356 9/20 0.55
▸ PGGT1B P53609 1/20 0.48
▸ HSD17B10 Q99714 2/20 0.40
▸ ALDH1A1 P00352 2/20 0.40
▸ HPGD P15428 2/20 0.40
▸ USP2 O75604 1/20 0.40
▸ KDM4E B2RXH2 3/20 0.36
▸ IDO1 P14902 2/20 0.35
▸ KCNH2 Q12809 2/20 0.35
▸ LMNA P02545 2/20 0.35
▸ CYP1A2 P05177 1/20 0.35
▸ OPRM1 P35372 1/20 0.35
▸ OPRK1 P41145 1/20 0.35
▸ GAA P10253 1/20 0.35
▸ CDK4 P11802 1/20 0.35
▸ CCND1 P24385 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7207696 0.82 FNTA (0.56) FNTAFNTBPGGT1BALDH1A1HPGD
SCHEMBL3521134 0.81 FNTA (0.56) FNTAFNTBPGGT1BCYP1A2
SCHEMBL4428705 0.81 FNTA (0.56) FNTAFNTBPGGT1BHSD17B10ALDH1A1
SCHEMBL4434794 0.76 FNTA (0.47) FNTAFNTBPGGT1BKDM4EOPRM1
SCHEMBL7208658 0.75 FNTA (0.56) FNTAFNTBPGGT1BALDH1A1KDM4E
Water SCHEMBL7207857 0.75 FNTA (0.67) FNTAFNTBPGGT1B
SCHEMBL4424967 0.74 FNTA (0.46) FNTAFNTBPGGT1BALDH1A1KDM4E
SCHEMBL4426275 0.73 FNTA (0.55) FNTAFNTBPGGT1BHSD17B10ALDH1A1
SCHEMBL29445867 0.73 FNTA (0.53) FNTAFNTBPGGT1BHSD17B10ALDH1A1
SCHEMBL4434774 0.72 FNTA (0.75) FNTAFNTBPGGT1BHSD17B10ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0970079-B1 FARNESYL TRANSFERASE INHIBITING 1,8-ANNELATED QUINOLINONE DERIVATIVES SUBSTITUTED WITH N- OR C-LINKED IMIDAZOLES JANSSEN PHARMACEUTICA NV (BE) 2003-10-01 — — EP disclosed
US-6444812-B1 SUCH AS 7-(3-CHLOROPHENYL)-9-((4-CHLOROPHENYL)-1H-IMIDAZOL-1-YLMETHYL)-2,3-DIHYDRO -1H,5H-BENZO(IJ) QUINOLIZIN-5-ONE; FOR FORMING ONCOGENES FOR SIGNALLING TRANSFORMATION OF TUMOR CELLS JANSSEN PHARMACEUTICA N.V. (BE) 2002-09-03 — — US disclosed
US-20020049327-A1 Farnesyl transferase inhibiting 1,8-annelated quinolinone derivatives substituted with N- or C-linked imidazoles VENET MARC GASTON (FR) 2002-04-25 — — US disclosed
US-6187786-B1 ANTITUMOR AND ANTICARCINOGENIC AGENTS JANSSEN PHARMACEUTICA N.V. (BE) 2001-02-13 — — US disclosed
EP-0970079-A1 FARNESYL TRANSFERASE INHIBITING 1,8-ANNELATED QUINOLINONE DERIVATIVES SUBSTITUTED WITH N- OR C-LINKED IMIDAZOLES JANSSEN PHARMACEUTICA N.V. (BE) 2000-01-12 — — EP disclosed
WO-1998040383-A1 FARNESYL TRANSFERASE INHIBITING 1,8-ANNELATED QUINOLINONE DERIVATIVES SUBSTITUTED WITH N- OR C-LINKED IMIDAZOLES JANSSEN PHARMACEUTICA N.V. (BE) 1998-09-17 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020049327-A1 Farnesyl transferase inhibiting 1,8-annelated quinolinone derivatives substituted with N- or C-linked imidazoles HCCS, CYP7A1, DHCR7 FNTA 4/4885FNTB 5/4885PGGT1B 142/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.