Sugi Predict

Sugi Predict / Compounds / SCHEMBL7207696

SCHEMBL7207696

SCHEMBL7207696

O=c1cc(-c2cccc(Cl)c2)c2cc(C(O)c3ccc(Cl)cc3)cc3c2n1CCO3

nearest known ligand 0.56

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ FNTA P49354 11/20 0.56
▸ FNTB P49356 11/20 0.56
▸ PGGT1B P53609 1/20 0.40
▸ IDO1 P14902 1/20 0.36
▸ KCNH2 Q12809 1/20 0.36
▸ CA12 O43570 1/20 0.33
▸ CA9 Q16790 1/20 0.33
▸ MCL1 Q07820 1/20 0.33
▸ LMNA P02545 1/20 0.33
▸ ALDH1A1 P00352 1/20 0.33
▸ GLA P06280 1/20 0.33
▸ MAPT P10636 1/20 0.33
▸ HPGD P15428 1/20 0.33
▸ ATM Q13315 1/20 0.33
▸ SMN1; SMN2 Q16637 1/20 0.33
▸ TDP1 Q9NUW8 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7207710 0.89 FNTA (0.55) FNTAFNTBPGGT1BIDO1KCNH2
SCHEMBL7209481 0.84 FNTA (0.59) FNTAFNTBPGGT1BCA12CA9
SCHEMBL7203407 0.82 FNTA (0.55) FNTAFNTBPGGT1BIDO1KCNH2
SCHEMBL7209530 0.79 FNTA (0.53) FNTAFNTBPGGT1BCA12CA9
SCHEMBL7210122 0.72 FNTA (0.54) FNTAFNTBPGGT1B
SCHEMBL4432840 0.71 FNTA (0.56) FNTAFNTBPGGT1BCA12CA9
SCHEMBL27509993 0.69 IDO1 (0.34) FNTAFNTBIDO1KCNH2LMNA
SCHEMBL7208658 0.66 FNTA (0.56) FNTAFNTBPGGT1BALDH1A1MAPT
SCHEMBL4434794 0.65 FNTA (0.47) FNTAFNTBPGGT1BMAPT
SCHEMBL6869864 0.65 FNTA (0.49) FNTAFNTBALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0970079-B1 FARNESYL TRANSFERASE INHIBITING 1,8-ANNELATED QUINOLINONE DERIVATIVES SUBSTITUTED WITH N- OR C-LINKED IMIDAZOLES JANSSEN PHARMACEUTICA NV (BE) 2003-10-01 — — EP disclosed
US-6444812-B1 SUCH AS 7-(3-CHLOROPHENYL)-9-((4-CHLOROPHENYL)-1H-IMIDAZOL-1-YLMETHYL)-2,3-DIHYDRO -1H,5H-BENZO(IJ) QUINOLIZIN-5-ONE; FOR FORMING ONCOGENES FOR SIGNALLING TRANSFORMATION OF TUMOR CELLS JANSSEN PHARMACEUTICA N.V. (BE) 2002-09-03 — — US disclosed
US-20020049327-A1 Farnesyl transferase inhibiting 1,8-annelated quinolinone derivatives substituted with N- or C-linked imidazoles VENET MARC GASTON (FR) 2002-04-25 — — US disclosed
EP-0970079-A1 FARNESYL TRANSFERASE INHIBITING 1,8-ANNELATED QUINOLINONE DERIVATIVES SUBSTITUTED WITH N- OR C-LINKED IMIDAZOLES JANSSEN PHARMACEUTICA N.V. (BE) 2000-01-12 — — EP disclosed
WO-1998040383-A1 FARNESYL TRANSFERASE INHIBITING 1,8-ANNELATED QUINOLINONE DERIVATIVES SUBSTITUTED WITH N- OR C-LINKED IMIDAZOLES JANSSEN PHARMACEUTICA N.V. (BE) 1998-09-17 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020049327-A1 Farnesyl transferase inhibiting 1,8-annelated quinolinone derivatives substituted with N- or C-linked imidazoles HCCS, CYP7A1, DHCR7 FNTA 4/4885FNTB 5/4885PGGT1B 142/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.