Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 1/20 | 0.44 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.41 |
| ▸ | CPB2 | Q96IY4 | 3/20 | 0.40 |
| ▸ | GSR | P00390 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | GGT1 | P19440 | 1/20 | 0.35 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.35 |
| ▸ | ODC1 | P11926 | 1/20 | 0.34 |
| ▸ | GNPAT | O15228 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7603037 | 1.00 | FOLH1 (0.44) | FOLH1RNPEPCPB2GSRMMP2 | |
| SCHEMBL7198450 | 0.95 | FOLH1 (0.50) | FOLH1RNPEPCPB2GSRMMP2 | |
| SCHEMBL8734 | 0.85 | FOLH1 (0.46) | FOLH1RNPEPCPB2GSRMMP2 | |
| SCHEMBL8735 | 0.85 | FOLH1 (0.46) | FOLH1RNPEPCPB2GSRMMP2 | |
| SCHEMBL10436332 | 0.85 | FOLH1 (0.46) | FOLH1RNPEPCPB2GSRMMP2 | |
| SCHEMBL2873029 | 0.85 | FOLH1 (0.46) | FOLH1RNPEPCPB2GSRMMP2 | |
| SCHEMBL10436330 | 0.85 | FOLH1 (0.46) | FOLH1RNPEPCPB2GSRMMP2 | |
| Hydrochloric Acid SCHEMBL1560135 | 0.83 | FOLH1 (0.45) | FOLH1RNPEPCPB2GSRMMP2 | |
| Hydrochloric Acid SCHEMBL1560136 | 0.83 | FOLH1 (0.45) | FOLH1RNPEPCPB2GSRMMP2 | |
| Hydrochloric Acid SCHEMBL21933053 | 0.81 | FOLH1 (0.44) | FOLH1RNPEPCPB2GSRMMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6602910-B2 | Treating cancer in a patient comprising administering an effective amount of substantially purified D enantiomer of difluoromethylornithine | ILEX ONCOLOGY, INC. | 2003-08-05 | — | — | US | disclosed |
| EP-1261326-A1 | D-ENANTIOMER OF DFMO AND METHODS OF USE THEREFOR FOR TREATING CANCER | Ilex Oncology, Inc. (US) | 2002-12-04 | — | — | EP | disclosed |
| US-20020045663-A1 | D-enantiomer of DFMO and methods of use therefor | ILEX ONCOLOGY, INC. (US) | 2002-04-18 | — | — | US | disclosed |
| WO-2001068076-A2 | D-ENANTIOMER OF DFMO AND METHODS OF USE THEREOF FOR TREATING CANCER | ILEX ONCOLOGY, INC. (US) | 2001-09-20 | — | — | WO | disclosed |
| US-6008386-A | ALPHA-AMINO ACIDS BEARING AN OXIRANE RING ON THE ALPHA CARBON IN PLACE OF THE ALPHA-PROTON; IRREVERSIBLE INHIBITORS FOR AMINO ACID DECARBOXYLASES | BOARD OF REGENTS UNIVERSITY OF NEBRASKA-LINCOLN (US) | 1999-12-28 | — | — | US | disclosed |
| US-5705660-A | Method for the synthesis of α-oxiranyl amino acids | BOARD OF REGENTS, UNIVERSITY OF NEBRASKA-LINCOLN | 1998-01-06 | — | — | US | disclosed |
| EP-0326766-A1 | 5-Substituted ornithine derivatives | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-08-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020045663-A1 | D-enantiomer of DFMO and methods of use therefor | DHODH, DDT, HADHB | FOLH1 39/4885RNPEP 1764/4885CPB2 2478/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.