Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ODC1 known ✓ | P11926 | 1/20 | 0.35 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.45 |
| ▸ | CPB2 | Q96IY4 | 4/20 | 0.41 |
| ▸ | GSR | P00390 | 1/20 | 0.39 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | GGT1 | P19440 | 1/20 | 0.36 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | GNPAT | O15228 | 1/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1560136 | 1.00 | FOLH1 (0.45) | FOLH1CPB2GSRRNPEPBLM | |
| Hydrochloric Acid SCHEMBL21933053 | 0.98 | FOLH1 (0.44) | FOLH1CPB2GSRRNPEPBLM | |
| SCHEMBL8734 | 0.98 | FOLH1 (0.46) | FOLH1CPB2GSRRNPEPBLM | |
| SCHEMBL8735 | 0.98 | FOLH1 (0.46) | FOLH1CPB2GSRRNPEPBLM | |
| SCHEMBL2873029 | 0.98 | FOLH1 (0.46) | FOLH1CPB2GSRRNPEPBLM | |
| SCHEMBL6479470 | 0.92 | FOLH1 (0.53) | FOLH1CPB2GSRRNPEPMMP2 | |
| SCHEMBL6479474 | 0.92 | FOLH1 (0.53) | FOLH1CPB2GSRRNPEPMMP2 | |
| Ornithine SCHEMBL3820639 | 0.90 | GSR (0.56) | FOLH1GSR | |
| Benzoquinone SCHEMBL28214836 | 0.87 | FOLH1 (0.39) | FOLH1CPB2GSRRNPEPMMP2 | |
| SCHEMBL7603037 | 0.83 | FOLH1 (0.44) | FOLH1CPB2GSRRNPEPBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2303288-A2 | CONJUGATES OF A POLYMER, A BISPHOSPHONATE AND AN ANTI-ANGIOGENESIS AGENT AND USES THEREOF IN THE TREATMENT AND MONITORING OF BONE RELATED DISEASES | Ramot at Tel-Aviv University Ltd. (IL) | 2011-04-06 | — | — | EP | claimed |
| WO-2009141823-A2 | CONJUGATES OF A POLYMER, A BISPHOSPHONATE AND AN ANTI-ANGIOGENESIS AGENT AND USES THEREOF IN THE TREATMENT AND MONITORING OF BONE RELATED DISEASES | RAMOT AT TEL AVIV UNIVERSITY LTD. (IL) | 2009-11-26 | — | — | WO | claimed |
| WO-2008157230-A1 | RSK INHIBITORS AS ANTI-ANGIOGENIC THERAPEUTICS | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2008-12-24 | — | — | WO | claimed |
| CN-112481337-B | High mannose glycoform content of regulatory ornithine metabolism to manipulate recombinant proteins | 美国安进公司 | 2024-06-25 | — | — | CN | disclosed |
| WO-2023081681-A1 | NITRIC OXIDE DONORS FOR USE IN SURGICAL RECOVERY | BAXTER INTERNATIONAL INC. (US) | 2023-05-11 | — | — | WO | disclosed |
| CN-115531555-A | Application of mannose-modified nanoparticles in preparation of drug for treating osteosarcoma | 上海市第一人民医院 | 2022-12-30 | — | — | CN | disclosed |
| CN-113072456-B | Chiral alpha-difluoromethyl amino acid compound and preparation method thereof | 中国科学技术大学 | 2022-04-19 | — | — | CN | disclosed |
| US-11254963-B2 | Increasing ornithine accumulation to increase high mannose glycoform content of recombinant proteins | AMGEN INC. (US) | 2022-02-22 | — | — | US | disclosed |
| CN-112481337-A | Modulation of ornithine metabolism to manipulate high mannose glycoform content of recombinant proteins | 美国安进公司 | 2021-03-12 | — | — | CN | disclosed |
| CN-106029896-B | Modulation of ornithine metabolism to manipulate high mannose glycoform content of recombinant proteins | 美国安进公司 | 2020-10-27 | — | — | CN | disclosed |
| US-20200071738-A1 | DECREASING ORNITHINE METABOLISM TO DECREASE THE HIGH MANNOSE GLYCOFORM CONTENT OF RECOMBINANT PROTEINS | AMGEN INC. (US) | 2020-03-05 | — | — | US | disclosed |
| EP-2303288-A2 | CONJUGATES OF A POLYMER, A BISPHOSPHONATE AND AN ANTI-ANGIOGENESIS AGENT AND USES THEREOF IN THE TREATMENT AND MONITORING OF BONE RELATED DISEASES | Ramot at Tel-Aviv University Ltd. (IL) | 2011-04-06 | — | — | EP | disclosed |
| WO-2009141823-A2 | CONJUGATES OF A POLYMER, A BISPHOSPHONATE AND AN ANTI-ANGIOGENESIS AGENT AND USES THEREOF IN THE TREATMENT AND MONITORING OF BONE RELATED DISEASES | RAMOT AT TEL AVIV UNIVERSITY LTD. (IL) | 2009-11-26 | — | — | WO | disclosed |
| WO-2009141826-A2 | NOVEL CONJUGATES OF POLYMERS HAVING A THERAPEUTICALLY ACTIVE AGENT AND AN ANGIOGENESIS TARGETING MOIETY ATTACHED THERETO AND USES THEREOF IN THE TREATMENT OF ANGIOGENESIS RELATED DISEASES | RAMOT AT TEL AVIV UNIVERSITY LTD. (IL) | 2009-11-26 | — | — | WO | disclosed |
| WO-2008157230-A1 | RSK INHIBITORS AS ANTI-ANGIOGENIC THERAPEUTICS | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2008-12-24 | — | — | WO | disclosed |
| US-7045550-B2 | Polyamines and analogs for protecting cells during cancer chemotherapy and radiotherapy | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2006-05-16 | — | — | US | disclosed |
| US-20030118539-A1 | Polyamines and analogs for protecting cells during cancer chemotherapy and radiotherapy | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2003-06-26 | — | — | US | disclosed |
| WO-2003013245-A1 | POLYAMINES AND ANALOGS FOR PROTECTING CELLS DURING CANCER CHEMOTHERAPY AND RADIOTHERAPY | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2003-02-20 | — | — | WO | disclosed |
| EP-1278537-A2 | METHODS FOR STIMULATING NERVOUS SYSTEM REGENERATION AND REPAIR BY REGULATING ARGINASE I AND POLYAMINE SYNTHESIS | The Research Foundation of the City University of New York (US) | 2003-01-29 | — | — | EP | disclosed |
| WO-2001085981-A2 | METHODS FOR STIMULATING NERVOUS SYSTEM REGENERATION AND REPAIR BY REGULATING ARGINASE I AND POLYAMINE SYNTHESIS | RESEARCH FOUNDATION OF CITY UNIVERSITY OF NEW YORK (US) | 2001-11-15 | — | — | WO | disclosed |