Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.97 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.97 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.97 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.97 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.80 |
| ▸ | GAA | P10253 | 2/20 | 0.80 |
| ▸ | TP53 | P04637 | 3/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.78 |
| ▸ | HPGD | P15428 | 2/20 | 0.78 |
| ▸ | HTT | P42858 | 2/20 | 0.78 |
| ▸ | PKM | P14618 | 1/20 | 0.78 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.78 |
| ▸ | POLB | P06746 | 2/20 | 0.75 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.75 |
| ▸ | NPC1 | O15118 | 1/20 | 0.65 |
| ▸ | CASP1 | P29466 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4608783 | 0.92 | PDE4A (0.88) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL10829942 | 0.84 | NPC1 (0.73) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL4180103 | 0.83 | PDE4A (0.71) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL23052377 | 0.82 | PDE4A (0.71) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL27480773 | 0.82 | PDE4A (0.72) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL30577313 | 0.81 | PDE4A (0.66) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL4172976 | 0.81 | PDE4A (0.69) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL9228437 | 0.80 | ALDH1A1 (0.71) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL7413456 | 0.80 | PDE4A (0.68) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL13850383 | 0.80 | NPC1 (0.68) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045690-B1 | BENZENESULFONAMIDE INHIBITORS OF PDE-IV AND THEIR THERAPEUTIC USE | WARNER LAMBERT CO (US) | 2003-04-23 | — | — | EP | claimed |
| US-6162830-A | Benzenesulfonamide inhibitors of PDE-IV and their therapeutic use | WARNER-LAMBERT COMPANY (US) | 2000-12-19 | — | — | US | claimed |
| EP-1045690-A1 | BENZENESULFONAMIDE INHIBITORS OF PDE-IV AND THEIR THERAPEUTIC USE | WARNER-LAMBERT COMPANY (US) | 2000-10-25 | — | — | EP | claimed |
| WO-1999026616-A1 | BENZENESULFONAMIDE INHIBITORS OF PDE-IV AND THEIR THERAPEUTIC USE | WARNER-LAMBERT COMPANY (US) | 1999-06-03 | — | — | WO | claimed |
| EP-1045690-B1 | BENZENESULFONAMIDE INHIBITORS OF PDE-IV AND THEIR THERAPEUTIC USE | WARNER LAMBERT CO (US) | 2003-04-23 | — | — | EP | disclosed |
| US-6162830-A | Benzenesulfonamide inhibitors of PDE-IV and their therapeutic use | WARNER-LAMBERT COMPANY (US) | 2000-12-19 | — | — | US | disclosed |
| EP-1045690-A1 | BENZENESULFONAMIDE INHIBITORS OF PDE-IV AND THEIR THERAPEUTIC USE | WARNER-LAMBERT COMPANY (US) | 2000-10-25 | — | — | EP | disclosed |
| WO-1999026616-A1 | BENZENESULFONAMIDE INHIBITORS OF PDE-IV AND THEIR THERAPEUTIC USE | WARNER-LAMBERT COMPANY (US) | 1999-06-03 | — | — | WO | disclosed |