Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 20/20 | 1.00 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | THPO | P40225 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7206171 | 0.99 | SIGMAR1 (1.00) | SIGMAR1MEN1LMNAMAPTPMP22 | |
| SCHEMBL7070370 | 0.92 | SIGMAR1 (0.85) | SIGMAR1TP53CYP2D6TSHRTHPO | |
| SCHEMBL7206334 | 0.84 | SIGMAR1 (0.73) | SIGMAR1 | |
| SCHEMBL6722611 | 0.84 | SIGMAR1 (0.73) | SIGMAR1 | |
| SCHEMBL6720958 | 0.83 | SIGMAR1 (0.73) | SIGMAR1TP53CYP2D6TSHRTHPO | |
| SCHEMBL7203955 | 0.82 | SIGMAR1 (0.69) | SIGMAR1 | |
| SCHEMBL6727640 | 0.78 | SIGMAR1 (0.63) | SIGMAR1TP53CYP2D6TSHRTHPO | |
| SCHEMBL6720673 | 0.78 | SIGMAR1 (0.63) | SIGMAR1LMNAMAPTKMT2A | |
| SCHEMBL7647473 | 0.77 | SIGMAR1 (0.74) | SIGMAR1TP53CYP2D6TSHRTHPO | |
| Hydrochloric Acid SCHEMBL7204073 | 0.77 | SIGMAR1 (0.64) | SIGMAR1MEN1LMNAMAPTPMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0705100-B1 | THERAPEUTIC SUBSTITUTED GUANIDINES | CENES LTD (GB) | 2003-07-30 | — | — | EP | disclosed |
| US-6156741-A | Therapeutic substituted guanidines | CAMBRIDGE NEUROSCIENCE, INC. (US) | 2000-12-05 | — | — | US | disclosed |
| US-6153604-A | Therapeutic substituted guanidines | CAMBRIDGE NEUROSCIENCE, INC. (US) | 2000-11-28 | — | — | US | disclosed |
| US-6147063-A | NEUROTOXICITY | CAMBRIDGE NEUROSCIENCE, INC. (US) | 2000-11-14 | — | — | US | disclosed |
| EP-0705100-A4 | THERAPEUTIC SUBSTITUTED GUANIDINES | CAMBRIDGE NEUROSCIENCE INC (US) | 1996-05-29 | — | — | EP | disclosed |
| EP-0705100-A1 | THERAPEUTIC SUBSTITUTED GUANIDINES | CAMBRIDGE NEUROSCIENCE, INC. (US) | 1996-04-10 | — | — | EP | disclosed |
| WO-1994027591-A1 | THERAPEUTIC SUBSTITUTED GUANIDINES | CAMBRIDGE NEUROSCIENCE, INC. (US) | 1994-12-08 | — | — | WO | disclosed |