Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ODC1 | P11926 | 2/20 | 0.88 |
| ▸ | ARG1 | P05089 | 9/20 | 0.47 |
| ▸ | ARG2 | P78540 | 6/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | BLM | P54132 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | PLG | P00747 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7204384 | 1.00 | ODC1 (0.88) | ODC1ARG1ARG2LMNABLM | |
| SCHEMBL3831417 | 0.94 | ODC1 (1.00) | ODC1ARG1ARG2LMNABLM | |
| SCHEMBL996766 | 0.94 | ODC1 (1.00) | ODC1ARG1ARG2LMNABLM | |
| SCHEMBL3831414 | 0.94 | ODC1 (1.00) | ODC1ARG1ARG2LMNABLM | |
| Hydrochloric Acid SCHEMBL10778576 | 0.92 | ODC1 (0.96) | ODC1ARG1ARG2LMNABLM | |
| Hydrochloric Acid SCHEMBL9586263 | 0.92 | ODC1 (0.96) | ODC1ARG1ARG2LMNABLM | |
| Hydrochloric Acid SCHEMBL9586259 | 0.92 | ODC1 (0.96) | ODC1ARG1ARG2LMNABLM | |
| Hydrochloric Acid SCHEMBL10556045 | 0.90 | ODC1 (0.92) | ODC1ARG1ARG2LMNABLM | |
| SCHEMBL29359936 | 0.85 | ODC1 (0.63) | ODC1ARG1ARG2LMNABLM | |
| SCHEMBL9501854 | 0.83 | ODC1 (0.61) | ODC1ARG1ARG2LMNABLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6187296-B1 | SUCH AS ALPHA-DIFLUOROMETHYL LYSINE (DEML) OR ALPHA-MONOFLUOROMETHYL LYSINE (MFML) | THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA | 2001-02-13 | — | — | US | claimed |
| US-6103220-A | Lysine decarboxylase inhibitors for the prevention and treatment of periodontal disease | THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA | 2000-08-15 | — | — | US | claimed |
| US-6602910-B2 | Treating cancer in a patient comprising administering an effective amount of substantially purified D enantiomer of difluoromethylornithine | ILEX ONCOLOGY, INC. | 2003-08-05 | — | — | US | disclosed |
| US-20020045663-A1 | D-enantiomer of DFMO and methods of use therefor | ILEX ONCOLOGY, INC. (US) | 2002-04-18 | — | — | US | disclosed |
| US-6187296-B1 | SUCH AS ALPHA-DIFLUOROMETHYL LYSINE (DEML) OR ALPHA-MONOFLUOROMETHYL LYSINE (MFML) | THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA | 2001-02-13 | — | — | US | disclosed |
| US-6103220-A | Lysine decarboxylase inhibitors for the prevention and treatment of periodontal disease | THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA | 2000-08-15 | — | — | US | disclosed |
| EP-0046710-B1 | PREPARATION OF AMINOACETONITRILE DERIVATIVES | MERRELL TORAUDE ET COMPAGNIE (FR) | 1984-06-13 | — | — | EP | disclosed |
| US-4405530-A | Process for preparing fluorinated amino-nitriles | MERRELL TORAUDE ET COMPAGNIE (FR) | 1983-09-20 | — | — | US | disclosed |
| EP-0046710-A1 | Preparation of aminoacetonitrile derivatives | MERRELL TORAUDE ET COMPAGNIE (FR) | 1982-03-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020045663-A1 | D-enantiomer of DFMO and methods of use therefor | DHODH, DDT, HADHB | ODC1 34/4885ARG1 605/4885ARG2 819/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.