Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.46 |
| ▸ | FPR3 | P25089 | 1/20 | 0.46 |
| ▸ | FPR2 | P25090 | 1/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.42 |
| ▸ | PDE8B | O95263 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.39 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.39 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.39 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.39 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL889104 | 1.00 | PRMT5 (0.46) | PRMT5FPR3FPR2KDM1ATRPV1 | |
| SCHEMBL12810103 | 0.97 | FPR3 (0.49) | PRMT5FPR3FPR2KDM1ATRPV1 | |
| SCHEMBL889008 | 0.92 | FPR3 (0.42) | PRMT5FPR3FPR2KDM1ATRPV1 | |
| SCHEMBL1598119 | 0.86 | HCRTR1 (0.49) | HCRTR1HCRTR2OPRD1ALOX5APFEN1 | |
| SCHEMBL1598122 | 0.86 | HCRTR1 (0.49) | HCRTR1HCRTR2OPRD1ALOX5APFEN1 | |
| SCHEMBL888987 | 0.85 | PRMT5 (0.48) | PRMT5FPR3FPR2KDM1ATRPV1 | |
| SCHEMBL1597840 | 0.85 | PRMT5 (0.44) | PRMT5FPR3FPR2KDM1ATRPV1 | |
| SCHEMBL1597836 | 0.85 | PRMT5 (0.44) | PRMT5FPR3FPR2KDM1ATRPV1 | |
| SCHEMBL1597402 | 0.85 | NPC1 (0.48) | PRMT5FPR3FPR2KDM1ATRPV1 | |
| SCHEMBL1597407 | 0.85 | NPC1 (0.48) | PRMT5FPR3FPR2KDM1ATRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003051368-A1 | N-AROYL CYCLIC AMINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2003-06-26 | — | — | WO | disclosed |