Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 11/20 | 0.68 |
| ▸ | HTR1A | P08908 | 3/20 | 0.68 |
| ▸ | HTR1D | P28221 | 8/20 | 0.59 |
| ▸ | HTR6 | P50406 | 6/20 | 0.55 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.51 |
| ▸ | DRD1 | P21728 | 1/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7207798 | 0.90 | HTR1B (0.61) | HTR1BHTR1AHTR1DHTR6CHRM2 | |
| SCHEMBL7204959 | 0.86 | HTR1B (0.68) | HTR1BHTR1AHTR1DHTR6CHRM2 | |
| SCHEMBL7207529 | 0.85 | HTR1B (0.62) | HTR1BHTR1AHTR1DHTR6CHRM2 | |
| SCHEMBL7200807 | 0.83 | HTR1B (0.61) | HTR1BHTR1AHTR1DHTR6CHRM2 | |
| SCHEMBL5819877 | 0.82 | HTR1B (1.00) | HTR1BHTR1AHTR1DHTR6 | |
| SCHEMBL5819875 | 0.82 | HTR1B (1.00) | HTR1BHTR1AHTR1DHTR6 | |
| SCHEMBL8790464 | 0.82 | HTR1B (1.00) | HTR1BHTR1AHTR1DHTR6 | |
| SCHEMBL7202293 | 0.82 | HTR1B (0.62) | HTR1BHTR1AHTR1DHTR6CHRM2 | |
| SCHEMBL7202248 | 0.82 | HTR1B (0.62) | HTR1BHTR1AHTR1DHTR6CHRM2 | |
| SCHEMBL7204116 | 0.82 | HTR1B (0.62) | HTR1BHTR1AHTR1DHTR6CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6608079-B1 | Activating serotonin-1F receptors, inhibiting neuronal protein extravasation, treating migraine | ELI LILLY AND COMPANY | 2003-08-19 | — | — | US | disclosed |