Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | ADK | P55263 | 14/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8192179 | 1.00 | LMNA (0.54) | LMNAADKALDH1A1TSHRP2RY6 | |
| SCHEMBL7209579 | 0.89 | LMNA (0.58) | LMNAADKTSHRP2RY6SMN1; SMN2 | |
| SCHEMBL8214201 | 0.89 | LMNA (0.58) | LMNAADKTSHRP2RY6SMN1; SMN2 | |
| SCHEMBL3821161 | 0.88 | LMNA (0.56) | LMNAADKP2RY6 | |
| SCHEMBL7204636 | 0.87 | LMNA (0.56) | LMNAADKALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL7204792 | 0.87 | LMNA (0.59) | LMNAADKTSHRP2RY6SMN1; SMN2 | |
| SCHEMBL8192157 | 0.87 | LMNA (0.59) | LMNAADKTSHRP2RY6SMN1; SMN2 | |
| SCHEMBL8197032 | 0.87 | LMNA (0.56) | LMNAADKALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL3817196 | 0.86 | LMNA (0.53) | LMNAADKP2RY6 | |
| SCHEMBL3820963 | 0.86 | LMNA (0.66) | LMNAADKTSHRP2RY6SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1060183-B1 | 5'-DEOXYCYTIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | claimed |
| EP-1060183-B1 | 5'-DEOXYCYTIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| EP-1060183-A1 | 5'-DEOXYCYTIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-12-20 | — | — | EP | disclosed |
| WO-1999040099-A1 | 5'-DEOXYCYTIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-08-12 | — | — | WO | disclosed |