Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.35 |
| ▸ | ESR1 known ✓ | P03372 | 1/20 | 0.34 |
| ▸ | ESR2 known ✓ | Q92731 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | SLC13A5 | Q86YT5 | 6/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HMGCR | P04035 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL7204241 | 1.00 | ALDH1A1 (0.58) | ALDH1A1KDM4ETSHRLMNAMAPT | |
| Citric Acid SCHEMBL11179126 | 0.87 | ALDH1A1 (0.61) | ALDH1A1KDM4ETSHRLMNAMAPT | |
| Citric Acid SCHEMBL11188422 | 0.84 | ALDH1A1 (0.62) | ALDH1A1KDM4ETSHRLMNAMAPT | |
| Citric Acid SCHEMBL27835074 | 0.83 | ALDH1A1 (0.83) | ALDH1A1KDM4ETSHRLMNAMAPT | |
| Citric Acid SCHEMBL27541745 | 0.81 | KDM4E (0.55) | ALDH1A1KDM4ETSHRLMNAMAPT | |
| Citric Acid SCHEMBL11822428 | 0.81 | ALDH1A1 (0.55) | ALDH1A1KDM4ETSHRLMNAMAPT | |
| Citric Acid SCHEMBL28058231 | 0.81 | ALDH1A1 (0.71) | ALDH1A1KDM4ETSHRLMNAMAPT | |
| Citric Acid SCHEMBL6731419 | 0.81 | ALDH1A1 (0.79) | ALDH1A1KDM4ETSHRLMNAMAPT | |
| Citric Acid SCHEMBL28991913 | 0.81 | ALDH1A1 (0.79) | ALDH1A1KDM4ETSHRLMNAMAPT | |
| Citric Acid SCHEMBL664271 | 0.78 | ALDH1A1 (0.94) | ALDH1A1KDM4ETSHRLMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0910432-B1 | ENHANCED ELECTROTRANSPORT OF THERAPEUTIC AGENTS HAVING POLYBASIC ANIONIC COUNTER-IONS | ALZA CORP (US) | 2003-10-01 | — | — | EP | disclosed |
| US-6004577-A | DELIVERING THERAPUETIC AGENT THROUGH BODY SURFACE USING ELECTROTRANSPORT BY PLACING SOLUTION COMPIRSING THERAPUETIC AGENT AND METAL COMPOUND CAPABLE OF COMPOLEXING WITH POLYBASIC ANION | ALZA CORPORATION | 1999-12-21 | — | — | US | disclosed |
| EP-0910432-A1 | ENHANCED ELECTROTRANSPORT OF THERAPEUTIC AGENTS HAVING POLYBASIC ANIONIC COUNTER-IONS | ALZA CORPORATION (US) | 1999-04-28 | — | — | EP | disclosed |
| WO-1997047354-A1 | ENHANCED ELECTROTRANSPORT OF THERAPEUTIC AGENTS HAVING POLYBASIC ANIONIC COUNTER-IONS | ALZA CORPORATION (US) | 1997-12-18 | — | — | WO | disclosed |