Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 20/20 | 0.73 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | THPO | P40225 | 1/20 | 0.56 |
| ▸ | MTOR | P42345 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7207724 | 0.99 | SIGMAR1 (0.74) | SIGMAR1 | |
| SCHEMBL6716544 | 0.91 | SIGMAR1 (0.64) | SIGMAR1 | |
| Hydrochloric Acid SCHEMBL7202394 | 0.90 | SIGMAR1 (0.66) | SIGMAR1 | |
| SCHEMBL7205171 | 0.88 | SIGMAR1 (0.72) | SIGMAR1TP53CYP2D6TSHRTHPO | |
| SCHEMBL6717076 | 0.87 | SIGMAR1 (0.80) | SIGMAR1TP53CYP2D6TSHRTHPO | |
| SCHEMBL6719635 | 0.87 | SIGMAR1 (0.74) | SIGMAR1 | |
| Hydrochloric Acid SCHEMBL7201854 | 0.87 | SIGMAR1 (0.74) | SIGMAR1 | |
| Hydrochloric Acid SCHEMBL7205189 | 0.86 | SIGMAR1 (0.82) | SIGMAR1 | |
| Hydrochloric Acid SCHEMBL7210031 | 0.86 | SIGMAR1 (0.74) | SIGMAR1 | |
| SCHEMBL6727642 | 0.85 | SIGMAR1 (0.76) | SIGMAR1TP53CYP2D6TSHRTHPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0705100-B1 | THERAPEUTIC SUBSTITUTED GUANIDINES | CENES LTD (GB) | 2003-07-30 | — | — | EP | claimed |
| US-6156741-A | Therapeutic substituted guanidines | CAMBRIDGE NEUROSCIENCE, INC. (US) | 2000-12-05 | — | — | US | claimed |
| US-6153604-A | Therapeutic substituted guanidines | CAMBRIDGE NEUROSCIENCE, INC. (US) | 2000-11-28 | — | — | US | claimed |
| US-6147063-A | NEUROTOXICITY | CAMBRIDGE NEUROSCIENCE, INC. (US) | 2000-11-14 | — | — | US | claimed |
| EP-0705100-B1 | THERAPEUTIC SUBSTITUTED GUANIDINES | CENES LTD (GB) | 2003-07-30 | — | — | EP | disclosed |
| US-6153604-A | Therapeutic substituted guanidines | CAMBRIDGE NEUROSCIENCE, INC. (US) | 2000-11-28 | — | — | US | disclosed |