SCHEMBL7204873

SCHEMBL7204873

COC(=O)C1CCc2cc(F)cc(I)c2O1

nearest known ligand 0.34

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CYP4F2 P78329 1/20 0.34
CYP4A11 Q02928 1/20 0.34
HTR1B P28222 2/20 0.34
PARP1 P09874 4/20 0.34
NFKB1 P19838 2/20 0.33
NFKB2 Q00653 2/20 0.33
RELA Q04206 2/20 0.33
HDAC3 O15379 1/20 0.32
HDAC1 Q13547 1/20 0.32
HDAC2 Q92769 1/20 0.32
KCNH2 Q12809 1/20 0.32
ALDH1A1 P00352 2/20 0.31
HTT P42858 2/20 0.31
LMNA P02545 1/20 0.31
TSHR P16473 1/20 0.31
KDM4E B2RXH2 1/20 0.31
SLC6A4 P31645 1/20 0.30
SLC6A3 Q01959 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7209390 0.82 NFKB1 (0.39) CYP4F2CYP4A11HTR1BPARP1NFKB1
SCHEMBL8864178 0.81 HTR1B (0.33) CYP4F2CYP4A11HTR1BPARP1NFKB1
SCHEMBL4247567 0.78 HTR1B (0.51) HTR1BPARP1KCNH2ALDH1A1HTT
SCHEMBL7229977 0.76 CYP4F2 (0.52) CYP4F2CYP4A11NFKB1NFKB2RELA
SCHEMBL29601366 0.76 CYP4F2 (0.52) CYP4F2CYP4A11NFKB1NFKB2RELA
SCHEMBL2005546 0.76 CYP4F2 (0.52) CYP4F2CYP4A11NFKB1NFKB2RELA
SCHEMBL13762677 0.76 CYP4F2 (0.52) CYP4F2CYP4A11NFKB1NFKB2RELA
SCHEMBL15882879 0.73 NFKB1 (0.41) CYP4F2CYP4A11NFKB1NFKB2RELA
SCHEMBL23921839 0.71 SIRT2 (0.41) CYP4F2CYP4A11HTR1BNFKB1NFKB2
SCHEMBL19510834 0.71 CYP4F2 (0.35) CYP4F2CYP4A11HTR1BNFKB1NFKB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0714396-B1 VASOCONTRICTIVE DIHYDROBENZOPYRAN DERIVATIVES JANSSEN PHARMACEUTICA NV (BE) 2003-12-10 EP disclosed
US-6100268-A MIGRAINES JANSSEN PHARMACEUTICA, N.V. (BE) 2000-08-08 US disclosed
CN-1052006-C Dihydrobenzopyran derivatives as vasoconstrictors, preparation and use thereof JANSSEN PHARMACEUTICA NV (NL) 2000-05-03 CN disclosed
US-5824682-A Vasoconstrictive dihydrobenzopyran derivatives JANSSEN PHARMACEUTICA, N.V. (BE) 1998-10-20 US disclosed
CN-1129451-A Dihydrobenzopyran derivatives as vasoconstrictors JANSSEN PHARMACEUTICA NV (BE) 1996-08-21 CN disclosed
EP-0714396-A1 VASOCONTRICTIVE DIHYDROBENZOPYRAN DERIVATIVES JANSSEN PHARMACEUTICA N.V. (BE) 1996-06-05 EP disclosed
WO-1995005383-A1 VASOCONTRICTIVE DIHYDROBENZOPYRAN DERIVATIVES JANSSEN PHARMACEUTICA N.V. (BE) 1995-02-23 WO disclosed