Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCQ | Q04759 | 7/20 | 0.47 |
| ▸ | ESR1 | P03372 | 2/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | LYN | P07948 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.37 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7204875 | 0.82 | PRKCQ (0.53) | PRKCQESR1CYP19A1PRKCDLRRK2 | |
| SCHEMBL22777943 | 0.74 | PRKCQ (0.47) | PRKCQESR1CYP19A1PRKCDEGFR | |
| SCHEMBL2984262 | 0.74 | PRKCQ (0.55) | PRKCQESR1CYP19A1PRKCDLRRK2 | |
| SCHEMBL2984264 | 0.74 | HPGD (0.52) | PRKCQESR1PRKCDEGFRLYN | |
| SCHEMBL31264026 | 0.73 | KDM4E (0.51) | — | |
| SCHEMBL6550968 | 0.73 | KDM4E (0.51) | — | |
| SCHEMBL12129007 | 0.72 | SYK (0.55) | ESR1CYP19A1EGFRSYKMAOA | |
| SCHEMBL29581605 | 0.71 | MAPK14 (0.50) | EGFRSYKPIK3CDPIK3CAPIK3CB | |
| SCHEMBL2988851 | 0.70 | NPC1 (0.50) | PRKCQESR1CYP19A1SYKNOTUM | |
| SCHEMBL1145515 | 0.70 | PRKCQ (0.53) | PRKCQPRKCDEGFRLYNSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1343791-A2 | SUBSTITUTED TETRACYCLIC PYRIDOINDOLES AS SEROTONIN AGONISTS AND ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-09-17 | — | — | EP | disclosed |
| WO-2002059129-A2 | SUBSTITUTED TETRACYCLIC PYRIDOINDOLES AS SEROTONIN AGONISTS AND ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-08-01 | — | — | WO | disclosed |