Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCQ | Q04759 | 13/20 | 0.53 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.52 |
| ▸ | PRKCD | Q05655 | 6/20 | 0.43 |
| ▸ | LYN | P07948 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 2/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | PRKCH | P24723 | 1/20 | 0.41 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7204879 | 0.82 | PRKCQ (0.47) | PRKCQLRRK2PRKCDLYNESR1 | |
| SCHEMBL1145515 | 0.75 | PRKCQ (0.53) | PRKCQPRKCDLYNPRKCHPRKCE | |
| SCHEMBL22777943 | 0.74 | PRKCQ (0.47) | PRKCQPRKCDESR1PRKCHPRKCE | |
| SCHEMBL2984264 | 0.74 | HPGD (0.52) | PRKCQPRKCDLYNESR1ALDH1A1 | |
| SCHEMBL12129007 | 0.72 | SYK (0.55) | ESR1CYP19A1SYK | |
| SCHEMBL2933194 | 0.71 | PRKCQ (0.69) | PRKCQPRKCDLYNPRKCHPRKCE | |
| SCHEMBL2933197 | 0.71 | PRKCQ (0.69) | PRKCQPRKCDLYNPRKCHPRKCE | |
| SCHEMBL29330341 | 0.71 | PRKCQ (0.39) | PRKCQPRKCDESR1NOTUMKDM4E | |
| SCHEMBL22803563 | 0.71 | ESR1 (0.56) | ESR1NOTUMCYP19A1 | |
| SCHEMBL2936308 | 0.69 | PRKCQ (1.00) | PRKCQPRKCDLYNPRKCHPRKCE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1343791-A2 | SUBSTITUTED TETRACYCLIC PYRIDOINDOLES AS SEROTONIN AGONISTS AND ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-09-17 | — | — | EP | disclosed |
| WO-2002059129-A2 | SUBSTITUTED TETRACYCLIC PYRIDOINDOLES AS SEROTONIN AGONISTS AND ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-08-01 | — | — | WO | disclosed |