Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.88 |
| ▸ | TSHR | P16473 | 4/20 | 0.78 |
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.73 |
| ▸ | LMNA | P02545 | 3/20 | 0.68 |
| ▸ | THRB | P10828 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | USP2 | O75604 | 1/20 | 0.64 |
| ▸ | GLA | P06280 | 1/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.64 |
| ▸ | HTT | P42858 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7209087 | 0.98 | GPBAR1 (0.91) | GPBAR1TSHRMCOLN3ALDH1A1LMNA | |
| SCHEMBL6367892 | 0.95 | GPBAR1 (0.97) | GPBAR1TSHRMCOLN3ALDH1A1LMNA | |
| Sb-756050 SCHEMBL4174350 | 0.94 | GPBAR1 (1.00) | GPBAR1TSHRMCOLN3ALDH1A1LMNA | |
| SCHEMBL3830421 | 0.92 | GPBAR1 (0.90) | GPBAR1TSHRMCOLN3ALDH1A1LMNA | |
| SCHEMBL4184681 | 0.92 | GPBAR1 (0.90) | GPBAR1TSHRMCOLN3ALDH1A1LMNA | |
| SCHEMBL24263764 | 0.86 | MCOLN3 (0.70) | GPBAR1TSHRMCOLN3ALDH1A1LMNA | |
| SCHEMBL6118073 | 0.86 | MCOLN3 (0.70) | GPBAR1TSHRMCOLN3ALDH1A1LMNA | |
| SCHEMBL22116077 | 0.86 | MCOLN3 (0.70) | GPBAR1TSHRMCOLN3ALDH1A1LMNA | |
| SCHEMBL8305327 | 0.86 | LMNA (0.91) | GPBAR1TSHRMCOLN3ALDH1A1LMNA | |
| SCHEMBL4193765 | 0.86 | GPBAR1 (0.84) | GPBAR1TSHRMCOLN3ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045690-B1 | BENZENESULFONAMIDE INHIBITORS OF PDE-IV AND THEIR THERAPEUTIC USE | WARNER LAMBERT CO (US) | 2003-04-23 | — | — | EP | claimed |
| US-6162830-A | Benzenesulfonamide inhibitors of PDE-IV and their therapeutic use | WARNER-LAMBERT COMPANY (US) | 2000-12-19 | — | — | US | claimed |
| EP-1045690-A1 | BENZENESULFONAMIDE INHIBITORS OF PDE-IV AND THEIR THERAPEUTIC USE | WARNER-LAMBERT COMPANY (US) | 2000-10-25 | — | — | EP | claimed |
| WO-1999026616-A1 | BENZENESULFONAMIDE INHIBITORS OF PDE-IV AND THEIR THERAPEUTIC USE | WARNER-LAMBERT COMPANY (US) | 1999-06-03 | — | — | WO | claimed |
| EP-1045690-B1 | BENZENESULFONAMIDE INHIBITORS OF PDE-IV AND THEIR THERAPEUTIC USE | WARNER LAMBERT CO (US) | 2003-04-23 | — | — | EP | disclosed |
| US-6162830-A | Benzenesulfonamide inhibitors of PDE-IV and their therapeutic use | WARNER-LAMBERT COMPANY (US) | 2000-12-19 | — | — | US | disclosed |