Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.58 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.58 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.58 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.58 |
| ▸ | TLR7 | Q9NYK1 | 13/20 | 0.56 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.55 |
| ▸ | PI4KA | P42356 | 1/20 | 0.55 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.55 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.55 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.55 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.52 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.52 |
| ▸ | PNP | P00491 | 1/20 | 0.50 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.50 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7204649 | 0.94 | TLR7 (0.64) | PDE4APDE4BPDE4CPDE4DTLR7 | |
| SCHEMBL7211348 | 0.93 | TLR7 (0.60) | PDE4APDE4BPDE4CPDE4DTLR7 | |
| SCHEMBL7210234 | 0.90 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DTLR7 | |
| SCHEMBL7211099 | 0.90 | PDE4A (0.55) | PDE4APDE4BPDE4CPDE4DTLR7 | |
| SCHEMBL509407 | 0.89 | TLR7 (0.64) | PDE4APDE4BPDE4CPDE4DTLR7 | |
| SCHEMBL7212572 | 0.89 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4DTLR7 | |
| SCHEMBL7208702 | 0.88 | PDE4A (0.58) | PDE4APDE4BPDE4CPDE4DTLR7 | |
| SCHEMBL4133313 | 0.87 | TLR7 (0.57) | PDE4APDE4BPDE4CPDE4DTLR7 | |
| SCHEMBL7204698 | 0.87 | PDE4A (0.57) | PDE4APDE4BPDE4CPDE4DTLR7 | |
| SCHEMBL21076558 | 0.86 | TLR7 (0.57) | PDE4APDE4BPDE4CPDE4DTLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4278675-A | ADMINISTERING 9-CYCLOHEXYL-9H-ADENINE OR 9-BENZYL-2-N-PROPOXY-9H-ADENINE | BRISTOL-MYERS COMPANY (US) | 1981-07-14 | — | — | US | claimed |
| EP-1035123-B1 | NOVEL HETEROCYCLIC COMPOUNDS | SUMITOMO PHARMA (JP) | 2003-08-20 | — | — | EP | disclosed |
| US-6329381-B1 | INTERFERONS, VIRICIDES AND ANTICARCINOGENIC AGENTS | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2001-12-11 | — | — | US | disclosed |
| EP-1035123-A1 | NOVEL HETEROCYCLIC COMPOUNDS | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2000-09-13 | — | — | EP | disclosed |
| US-4278675-A | ADMINISTERING 9-CYCLOHEXYL-9H-ADENINE OR 9-BENZYL-2-N-PROPOXY-9H-ADENINE | BRISTOL-MYERS COMPANY (US) | 1981-07-14 | — | — | US | disclosed |
| US-4278675-A | ADMINISTERING 9-CYCLOHEXYL-9H-ADENINE OR 9-BENZYL-2-N-PROPOXY-9H-ADENINE | BRISTOL-MYERS COMPANY (US) | 1981-07-14 | — | — | US | disclosed |