Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ENPEP | Q07075 | 5/20 | 0.43 |
| ▸ | ANPEP | P15144 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | GABRP | O00591 | 2/20 | 0.37 |
| ▸ | GABRD | O14764 | 2/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.37 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11298080 | 0.84 | TDP1 (0.40) | TSHRCYP2D6NFKB1SLC6A2SLC6A4 | |
| SCHEMBL2518196 | 0.77 | CYP2D6 (0.50) | TSHRCYP2D6NFKB1SLC6A2SLC6A4 | |
| SCHEMBL176230 | 0.77 | CYP2D6 (0.50) | TSHRCYP2D6NFKB1SLC6A2SLC6A4 | |
| SCHEMBL8972056 | 0.76 | TSHR (0.53) | TSHRSLC6A2SLC6A4BLMSLC6A3 | |
| SCHEMBL18921054 | 0.76 | TSHR (0.53) | TSHRSLC6A2SLC6A4BLMSLC6A3 | |
| SCHEMBL2201794 | 0.75 | GRIK1 (0.47) | TSHRTDP1GRIK1GRIA1GRIA2 | |
| SCHEMBL2201786 | 0.75 | GRIK1 (0.47) | TSHRTDP1GRIK1GRIA1GRIA2 | |
| SCHEMBL1547587 | 0.75 | TSHR (0.53) | TSHRCYP2D6NFKB1SLC6A2SLC6A4 | |
| SCHEMBL90430 | 0.74 | TSHR (0.55) | TSHRCYP2D6NFKB1SLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL29425835 | 0.74 | GRIK1 (0.46) | TSHRTDP1GRIK1GRIA1GRIA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6605723-B2 | Reacting a protected amino acid ester with a 4-substituted butyric acid derivative, cyclizing the protected intermediate, benzylating and decarboxylating the intermediate, asymmetric hydrogenation using a catalyst | HOFFMAN-LA ROCHE INC. | 2003-08-12 | — | — | US | disclosed |
| US-20010037026-A1 | Process for the preparation of ethanesul fonyl-piperidine derivatives | EVOTEC INTERNATIONAL GMBH (DE) | 2001-11-01 | — | — | US | disclosed |
| EP-1136475-A1 | Piperidine and piperazine compounds for use in the treatment of Alzheimer | F. HOFFMANN-LA ROCHE AG (CH) | 2001-09-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010037026-A1 | Process for the preparation of ethanesul fonyl-piperidine derivatives | GRIN1, GRIN3A, GRIN2B | TSHR 1354/4885CYP2D6 662/4885NFKB1 467/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.