Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 9/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.45 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.45 |
| ▸ | PI4KA | P42356 | 1/20 | 0.44 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.44 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.44 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.44 |
| ▸ | PDE2A | O00408 | 2/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | NT5E | P21589 | 4/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.40 |
| ▸ | PNP | P00491 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7209134 | 0.88 | ADORA3 (0.47) | ADORA3ADORA2AADORA1ADORA2BPI4KA | |
| SCHEMBL7206711 | 0.83 | ADORA1 (0.46) | ADORA3ADORA2AADORA1ADORA2BNT5E | |
| SCHEMBL8100777 | 0.81 | PI4KA (0.32) | ADORA3PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL4152287 | 0.81 | ADORA3 (0.65) | ADORA3ADORA2AADORA1ADORA2BPI4KA | |
| SCHEMBL7208372 | 0.81 | ADORA3 (0.49) | ADORA3ADORA2AADORA1ADORA2BNT5E | |
| Acetic Acid SCHEMBL7206675 | 0.79 | ADORA3 (0.59) | ADORA3ADORA2AADORA1ADORA2BPDE2A | |
| SCHEMBL18512532 | 0.78 | PI4KA (0.59) | ADORA3ADORA2AADORA1ADORA2BPI4KA | |
| SCHEMBL14075797 | 0.77 | PI4KA (0.72) | ADORA3ADORA2AADORA1PI4KAPI4K2B | |
| SCHEMBL7202481 | 0.77 | PI4KA (0.72) | ADORA3ADORA2AADORA1PI4KAPI4K2B | |
| SCHEMBL4148537 | 0.77 | PI4KA (0.58) | ADORA3ADORA2AADORA1ADORA2BPI4KA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6610665-B1 | Treatment of inflammatory diseases, asthma or chronic obstructive pulmonary disease | SMITHKLINE BEECHAM CORPORATION | 2003-08-26 | — | — | US | disclosed |
| EP-1056759-B1 | 2-(PURIN-9-YL) -TETRAHYDROFURAN-3, 4-DIOL DERIVATIVES | GLAXO GROUP LTD (GB) | 2002-09-04 | — | — | EP | disclosed |
| EP-1056759-A1 | 2-(PURIN-9-YL) -TETRAHYDROFURAN-3, 4-DIOL DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2000-12-06 | — | — | EP | disclosed |
| WO-1999041267-A1 | 2-(PURIN-9-YL) -TETRAHYDROFURAN-3, 4-DIOL DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1999-08-19 | — | — | WO | disclosed |