Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 14/20 | 0.65 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.41 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.41 |
| ▸ | PLG | P00747 | 1/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.41 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.41 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.41 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7205473 | 1.00 | LSS (0.65) | LSSADAMTS4ADAMTS5PLGPRSS1 | |
| SCHEMBL7203223 | 0.89 | LSS (0.77) | LSS | |
| SCHEMBL7210419 | 0.89 | LSS (0.77) | LSS | |
| SCHEMBL7211557 | 0.89 | LSS (0.77) | LSS | |
| SCHEMBL4802554 | 0.89 | LSS (0.68) | LSSADAMTS4ADAMTS5 | |
| SCHEMBL4802548 | 0.89 | LSS (0.68) | LSSADAMTS4ADAMTS5 | |
| SCHEMBL7203457 | 0.88 | LSS (0.75) | LSS | |
| SCHEMBL4804091 | 0.87 | LSS (0.75) | LSSADAMTS4ADAMTS5 | |
| SCHEMBL4804102 | 0.87 | LSS (0.75) | LSSADAMTS4ADAMTS5 | |
| SCHEMBL4798732 | 0.84 | LSS (0.70) | LSSADAMTS4ADAMTS5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1311475-A1 | NOVEL AMINOCYCLOHEXANE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-05-21 | — | — | EP | disclosed |
| WO-2002014267-A1 | NOVEL AMINOCYCLOHEXANE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-02-21 | — | — | WO | disclosed |