Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.44 |
| ▸ | PI4KA | P42356 | 2/20 | 0.44 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.44 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.44 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.44 |
| ▸ | AHCY | P23526 | 1/20 | 0.42 |
| ▸ | EP300 | Q09472 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | TEK | Q02763 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2153195 | 0.92 | TSHR (0.45) | EGFRADORA2AALDH1A1TSHRHTT | |
| SCHEMBL2152998 | 0.87 | EGFR (0.44) | EGFRADORA2API4KAPI4K2BPI4K2A | |
| SCHEMBL24709730 | 0.82 | EGFR (0.65) | EGFRADORA2API4KAPI4K2BPI4K2A | |
| SCHEMBL6833359 | 0.80 | PDE4A (0.47) | EGFRADORA2API4KAPI4K2BPI4K2A | |
| SCHEMBL1565498 | 0.79 | ADORA2A (0.60) | EGFRADORA2API4KAPI4K2BPI4K2A | |
| SCHEMBL29728010 | 0.79 | ADORA2A (0.60) | EGFRADORA2API4KAPI4K2BPI4K2A | |
| SCHEMBL454627 | 0.78 | EGFR (0.47) | EGFRADORA2AKDRALDH1A1SRC | |
| SCHEMBL8340777 | 0.76 | DAPK1 (0.46) | KDRALDH1A1TSHRHPGDRAB9A | |
| SCHEMBL19847491 | 0.75 | MAPT (0.45) | ADORA2AAHCYALDH1A1HTTLMNA | |
| SCHEMBL6690200 | 0.74 | TDP1 (0.49) | ADORA2AALDH1A1TSHRHTTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6613873-B1 | Covalently bound to a polyamide backbone; given formula; exhibit increased sequence specificity and binding affinity; resistant to enzyme degradation | ISIS PHARMACEUTICALS, INC. | 2003-09-02 | — | — | US | disclosed |
| US-6414112-B1 | BIND COMPLEMENTARY NUCLEIC ACIDS MORE STRONGLY AND HAVE INCREASED SEQUENCE SPECIFICITY AND BINDING AFFINITY | BUCHARDT OLE (DE) | 2002-07-02 | — | — | US | disclosed |