Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.41 |
| ▸ | TMIGD3 | P0DMS9 | 3/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.41 |
| ▸ | PI4KA | P42356 | 1/20 | 0.41 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.41 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.41 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | PNP | P00491 | 1/20 | 0.40 |
| ▸ | AHCY | P23526 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2152998 | 0.91 | EGFR (0.44) | PDE4APDE4BPDE4CPDE4DEGFR | |
| SCHEMBL2153195 | 0.87 | TSHR (0.45) | PDE4APDE4BPDE4CPDE4DEGFR | |
| SCHEMBL19847501 | 0.82 | MAPT (0.44) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL19847491 | 0.82 | MAPT (0.45) | ADORA2ATMIGD3ADORA1MAPTKDM4E | |
| SCHEMBL7205594 | 0.80 | EGFR (0.48) | EGFRADORA2AADORA1PI4KAPI4K2B | |
| SCHEMBL19978373 | 0.80 | ALDH1A1 (0.43) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL21896378 | 0.80 | CDK1 (0.48) | ADORA2AADORA1ADORA2BPI4KAPI4K2B | |
| SCHEMBL8340777 | 0.78 | DAPK1 (0.46) | MAPTADORA3ALDH1A1HPGDKMT2A | |
| SCHEMBL8581230 | 0.73 | KMT2A (0.45) | ADORA2AMAPTKDM4EMAOBMEN1 | |
| SCHEMBL20275398 | 0.73 | NPC1 (0.48) | ADORA2AADORA2BPI4KAPI4K2BPI4K2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6756199-B1 | USED FOR THE SYNTHESIS OF BOTH PREDEFINED AND RANDOM SEQUENCE PEPTIDE NUCLEIC ACID OLIGOMERS | ISIS PHARMACEUTICALS, INC. | 2004-06-29 | — | — | US | disclosed |
| EP-0777678-A4 | — | — | 1997-07-16 | — | — | EP | disclosed |
| EP-0777678-A1 | PNA COMBINATORIAL LIBRARIES AND IMPROVED METHODS OF SYNTHESIS | ISIS PHARMACEUTICALS, INC. (US) | 1997-06-11 | — | — | EP | disclosed |
| WO-1995023163-A1 | PNA COMBINATORIAL LIBRARIES AND IMPROVED METHODS OF SYNTHESIS | ISIS PHARMACEUTICALS, INC. (US) | 1995-08-31 | — | — | WO | disclosed |