Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 6/20 | 0.44 |
| ▸ | EGFR | P00533 | 5/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.41 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7209982 | 0.99 | KIT (0.43) | KITEGFRKDREPHA2EPHB4 | |
| SCHEMBL7206430 | 0.90 | SMN1; SMN2 (0.46) | KITEGFRCHEK1ALDH1A1MAPK1 | |
| SCHEMBL7210146 | 0.90 | KIT (0.46) | KITEGFRKDREPHA2EPHB4 | |
| Hydrochloric Acid SCHEMBL7205053 | 0.90 | SMN1; SMN2 (0.46) | KITEGFRCHEK1ALDH1A1MAPK1 | |
| Hydrochloric Acid SCHEMBL7209863 | 0.89 | KIT (0.46) | KITEGFRKDREPHA2EPHB4 | |
| SCHEMBL4520501 | 0.84 | PDGFRB (0.43) | KITEGFRKDRCHEK1PDGFRB | |
| Hydrochloric Acid SCHEMBL7212126 | 0.83 | KIT (0.52) | KITEGFRKDRCHEK1SRC | |
| Acetic Acid SCHEMBL4520498 | 0.82 | EGFR (0.43) | EGFRKDRCHEK1SMN1; SMN2PDGFRB | |
| SCHEMBL7210071 | 0.82 | CHEK1 (0.52) | KITEGFRKDRCHEK1SRC | |
| SCHEMBL7211365 | 0.82 | CHEK1 (0.52) | KITEGFRKDRCHEK1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0912557-B1 | OXINDOLE DERIVATIVES | ASTRAZENECA AB (SE) | 2003-07-09 | — | — | EP | disclosed |
| US-6265411-B1 | ANGIOGENESIS INHIBITOR | ZENECA LIMITED (GB) | 2001-07-24 | — | — | US | disclosed |
| EP-0912557-A1 | OXINDOLE DERIVATIVES | ZENECA LIMITED (GB) | 1999-05-06 | — | — | EP | disclosed |
| WO-1997042187-A1 | OXINDOLE DERIVATIVES | ZENECA LIMITED (GB) | 1997-11-13 | — | — | WO | disclosed |