Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | KIT | P10721 | 6/20 | 0.45 |
| ▸ | PDE5A | O76074 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | ILK | Q13418 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7205053 | 0.99 | SMN1; SMN2 (0.46) | SMN1; SMN2ALDH1A1MAPK1CHEK1KDM4E | |
| SCHEMBL7210146 | 0.95 | KIT (0.46) | SMN1; SMN2ALDH1A1MAPK1CHEK1KDM4E | |
| Hydrochloric Acid SCHEMBL7209863 | 0.94 | KIT (0.46) | SMN1; SMN2ALDH1A1MAPK1CHEK1KDM4E | |
| SCHEMBL7205618 | 0.90 | KIT (0.44) | SMN1; SMN2ALDH1A1MAPK1CHEK1KIT | |
| Hydrochloric Acid SCHEMBL7209982 | 0.90 | KIT (0.43) | SMN1; SMN2ALDH1A1MAPK1CHEK1KIT | |
| Hydrochloric Acid SCHEMBL7212126 | 0.88 | KIT (0.52) | CHEK1KITEGFR | |
| SCHEMBL7211365 | 0.86 | CHEK1 (0.52) | CHEK1KITEGFR | |
| SCHEMBL7210071 | 0.86 | CHEK1 (0.52) | CHEK1KITEGFR | |
| Hydrochloric Acid SCHEMBL7205688 | 0.85 | CHEK1 (0.52) | CHEK1KITEGFR | |
| Hydrochloric Acid SCHEMBL8525709 | 0.83 | CHEK1 (0.50) | CHEK1KITEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0912557-B1 | OXINDOLE DERIVATIVES | ASTRAZENECA AB (SE) | 2003-07-09 | — | — | EP | disclosed |
| US-6265411-B1 | ANGIOGENESIS INHIBITOR | ZENECA LIMITED (GB) | 2001-07-24 | — | — | US | disclosed |
| EP-0912557-A1 | OXINDOLE DERIVATIVES | ZENECA LIMITED (GB) | 1999-05-06 | — | — | EP | disclosed |
| WO-1997042187-A1 | OXINDOLE DERIVATIVES | ZENECA LIMITED (GB) | 1997-11-13 | — | — | WO | disclosed |