Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | PDE4A | P27815 | 3/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.47 |
| ▸ | TAS2R14 | Q9NYV8 | 2/20 | 0.47 |
| ▸ | FLT1 | P17948 | 1/20 | 0.47 |
| ▸ | FLT4 | P35916 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7204252 | 0.80 | MAPT (0.72) | TSHRPOLBMAPK1MAPTCA12 | |
| SCHEMBL7770162 | 0.77 | KEAP1 (0.60) | PKMTAS2R14 | |
| SCHEMBL7204778 | 0.76 | TSHR (0.60) | TSHRPOLBMAPK1PKMHCRTR2 | |
| SCHEMBL4176914 | 0.76 | PDE4D (0.61) | TSHRPOLBMAPK1MAPTPDE4A | |
| SCHEMBL4187131 | 0.75 | TSHR (0.54) | TSHRPOLBMAPK1PKMHCRTR2 | |
| SCHEMBL4187420 | 0.74 | POLB (0.58) | TSHRPOLBMAPK1MAPTCA12 | |
| SCHEMBL7204680 | 0.74 | TSHR (0.58) | TSHRPOLBMAPK1HCRTR2MAPT | |
| SCHEMBL2397437 | 0.74 | POLB (0.58) | TSHRPOLBMAPK1PDE4APDE4B | |
| SCHEMBL7417394 | 0.73 | PDE4A (0.79) | TSHRMAPTPDE4APDE4BPDE4C | |
| SCHEMBL493489 | 0.73 | PDE4D (0.50) | TSHRPOLBMAPK1PKMHCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045690-B1 | BENZENESULFONAMIDE INHIBITORS OF PDE-IV AND THEIR THERAPEUTIC USE | WARNER LAMBERT CO (US) | 2003-04-23 | — | — | EP | claimed |
| US-6162830-A | Benzenesulfonamide inhibitors of PDE-IV and their therapeutic use | WARNER-LAMBERT COMPANY (US) | 2000-12-19 | — | — | US | claimed |