Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.65 |
| ▸ | HTR1D | P28221 | 9/20 | 0.64 |
| ▸ | HTR1B | P28222 | 7/20 | 0.64 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL10347551 | 0.91 | HTR1A (0.63) | HTR1AHTR1DHTR1BDRD2 | |
| SCHEMBL8891069 | 0.83 | HTR1D (0.46) | HTR1AHTR1DHTR1B | |
| SCHEMBL8891598 | 0.82 | HTR1A (0.67) | HTR1AHTR1DHTR1BDRD2 | |
| SCHEMBL8130073 | 0.82 | HTR1A (0.67) | HTR1AHTR1DHTR1BDRD2 | |
| SCHEMBL6890172 | 0.81 | HTR1A (0.65) | HTR1AHTR1DHTR1B | |
| Hydrochloric Acid SCHEMBL7716614 | 0.80 | HTR1A (0.64) | HTR1AHTR1DHTR1B | |
| SCHEMBL8890741 | 0.80 | HTR1A (0.67) | HTR1AHTR1DHTR1B | |
| SCHEMBL9261792 | 0.79 | HTR1A (0.63) | HTR1AHTR1DHTR1BDRD2 | |
| SCHEMBL9534053 | 0.79 | HTR1A (0.54) | HTR1AHTR1DHTR1B | |
| SCHEMBL8889776 | 0.79 | HTR1A (0.83) | HTR1AHTR1DHTR1BDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0153083-B1 | 6-SUBSTITUTED-4-DIALKYLAMINOTETRAHYDROBENZ(C,D)INDOLES | ELI LILLY AND COMPANY (US) | 1990-05-23 | — | — | EP | claimed |
| EP-0153083-A2 | 6-Substituted-4-dialkylaminotetrahydrobenz(c,d)indoles | ELI LILLY AND COMPANY (US) | 1985-08-28 | — | — | EP | claimed |
| EP-0471576-B1 | 6-substituted-tetrahydrobenz[cd]indoles | LILLY CO ELI (US) | 2003-03-12 | — | — | EP | disclosed |
| US-5292766-A | Method for improving primary memory and/or learning | ELI LILLY AND COMPANY (US) | 1994-03-08 | — | — | US | disclosed |
| EP-0565274-A1 | 5-Ht1A agonists for improving primary memory and/or learning | ELI LILLY AND COMPANY (US) | 1993-10-13 | — | — | EP | disclosed |
| US-5229409-A | Antidepressant, tranquilizer | ELI LILLY AND COMPANY (US) | 1993-07-20 | — | — | US | disclosed |
| EP-0285278-B1 | The use of tetrahydrobenz[C,D]indole-6-carboxamides for the preparation of a medicament for the treating anxiety | ELI LILLY AND COMPANY (US) | 1992-08-12 | — | — | EP | disclosed |
| EP-0153083-B1 | 6-SUBSTITUTED-4-DIALKYLAMINOTETRAHYDROBENZ(C,D)INDOLES | ELI LILLY AND COMPANY (US) | 1990-05-23 | — | — | EP | disclosed |
| US-4758663-A | Isoindoline compound | BASF AKTIENGESELLSCHAFT (DE) | 1988-07-19 | — | — | US | disclosed |
| US-4576959-A | ANTIDEPRESSANTS | ELI LILLY AND COMPANY (US) | 1986-03-18 | — | — | US | disclosed |
| EP-0153083-A2 | 6-Substituted-4-dialkylaminotetrahydrobenz(c,d)indoles | ELI LILLY AND COMPANY (US) | 1985-08-28 | — | — | EP | disclosed |