Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EHMT2 | Q96KQ7 | 7/20 | 0.52 |
| ▸ | EHMT1 | Q9H9B1 | 7/20 | 0.52 |
| ▸ | KDR | P35968 | 6/20 | 0.50 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.50 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.50 |
| ▸ | KIT | P10721 | 3/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.47 |
| ▸ | FLT4 | P35916 | 2/20 | 0.47 |
| ▸ | TEK | Q02763 | 2/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.47 |
| ▸ | EGFR | P00533 | 2/20 | 0.47 |
| ▸ | SRC | P12931 | 2/20 | 0.47 |
| ▸ | PLK4 | O00444 | 1/20 | 0.47 |
| ▸ | GAK | O14976 | 1/20 | 0.47 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.47 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.47 |
| ▸ | ERN1 | O75460 | 1/20 | 0.47 |
| ▸ | STK10 | O94804 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7205559 | 0.99 | EHMT2 (0.52) | EHMT2EHMT1KDRTLR9TLR7 | |
| SCHEMBL7209523 | 0.96 | KDR (0.49) | EHMT2EHMT1KDRTLR9TLR7 | |
| Hydrochloric Acid SCHEMBL7209557 | 0.95 | KDR (0.48) | EHMT2EHMT1KDRTLR9TLR7 | |
| SCHEMBL7205019 | 0.93 | CHEK1 (0.58) | KDRCHEK1AURKBEGFRSRC | |
| SCHEMBL7211414 | 0.93 | CHEK1 (0.58) | KDRCHEK1AURKBEGFRSRC | |
| Hydrochloric Acid SCHEMBL7211395 | 0.92 | CHEK1 (0.57) | KDRCHEK1AURKBEGFRSRC | |
| SCHEMBL7205793 | 0.86 | KDR (0.48) | KDRFGFR1FLT1 | |
| SCHEMBL7205653 | 0.85 | PDE4A (0.45) | KDRPDGFRBEGFRLCKCSF1R | |
| SCHEMBL5500150 | 0.84 | ATM (0.49) | EHMT2EHMT1KDRPDGFRBEGFR | |
| SCHEMBL7206414 | 0.83 | KDR (0.46) | KDRFGFR1FLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0912557-B1 | OXINDOLE DERIVATIVES | ASTRAZENECA AB (SE) | 2003-07-09 | — | — | EP | disclosed |
| US-6265411-B1 | ANGIOGENESIS INHIBITOR | ZENECA LIMITED (GB) | 2001-07-24 | — | — | US | disclosed |
| EP-0912557-A1 | OXINDOLE DERIVATIVES | ZENECA LIMITED (GB) | 1999-05-06 | — | — | EP | disclosed |
| WO-1997042187-A1 | OXINDOLE DERIVATIVES | ZENECA LIMITED (GB) | 1997-11-13 | — | — | WO | disclosed |