Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 9/20 | 0.49 |
| ▸ | EGFR | P00533 | 5/20 | 0.49 |
| ▸ | ATM | Q13315 | 2/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.48 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.48 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.46 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | FLT1 | P17948 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 2/20 | 0.45 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.45 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7209557 | 0.99 | KDR (0.48) | KDREGFRATMAURKAEPHA2 | |
| SCHEMBL7206149 | 0.96 | EHMT2 (0.52) | KDREGFRAURKAEPHB4EHMT2 | |
| Hydrochloric Acid SCHEMBL7205559 | 0.95 | EHMT2 (0.52) | KDREGFRAURKAEPHB4EHMT2 | |
| SCHEMBL7211414 | 0.88 | CHEK1 (0.58) | KDREGFRATMAURKARET | |
| SCHEMBL7205019 | 0.88 | CHEK1 (0.58) | KDREGFRATMAURKARET | |
| SCHEMBL5500150 | 0.88 | ATM (0.49) | KDREGFRATMAURKAEPHA2 | |
| Hydrochloric Acid SCHEMBL7211395 | 0.88 | CHEK1 (0.57) | KDREGFRATMAURKARET | |
| SCHEMBL7211883 | 0.87 | CHEK1 (0.53) | AURKAPDGFRB | |
| SCHEMBL7205793 | 0.86 | KDR (0.48) | KDRFGFR1FLT1 | |
| Hydrochloric Acid SCHEMBL7206178 | 0.86 | CHEK1 (0.52) | AURKAPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0912557-B1 | OXINDOLE DERIVATIVES | ASTRAZENECA AB (SE) | 2003-07-09 | — | — | EP | disclosed |
| US-6265411-B1 | ANGIOGENESIS INHIBITOR | ZENECA LIMITED (GB) | 2001-07-24 | — | — | US | disclosed |
| EP-0912557-A1 | OXINDOLE DERIVATIVES | ZENECA LIMITED (GB) | 1999-05-06 | — | — | EP | disclosed |
| WO-1997042187-A1 | OXINDOLE DERIVATIVES | ZENECA LIMITED (GB) | 1997-11-13 | — | — | WO | disclosed |