Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 16/20 | 0.49 |
| ▸ | DHODH | Q02127 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.41 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.41 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.41 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6727803 | 0.88 | SIGMAR1 (0.63) | SIGMAR1DHODH | |
| Hydrochloric Acid SCHEMBL7201788 | 0.86 | SIGMAR1 (0.64) | SIGMAR1DHODH | |
| SCHEMBL6720798 | 0.83 | SIGMAR1 (0.49) | SIGMAR1DHODHMAPT | |
| SCHEMBL6720629 | 0.82 | SIGMAR1 (0.46) | SIGMAR1DHODHMAPTHDAC3HDAC4 | |
| SCHEMBL6719747 | 0.82 | SIGMAR1 (0.43) | SIGMAR1MAPTGRIN2DGRIN3BGRIN1 | |
| SCHEMBL6725035 | 0.82 | SIGMAR1 (0.62) | SIGMAR1MAPTGRIN2DGRIN3BGRIN1 | |
| Hydrochloric Acid SCHEMBL7410846 | 0.81 | SIGMAR1 (0.60) | SIGMAR1MAPTGAA | |
| SCHEMBL6724375 | 0.81 | SIGMAR1 (0.54) | SIGMAR1DHODHGAA | |
| SCHEMBL27501244 | 0.81 | SIGMAR1 (0.40) | SIGMAR1MAPTGRIN2DGRIN3BGRIN1 | |
| SCHEMBL6719226 | 0.80 | SIGMAR1 (0.53) | SIGMAR1MAPTGRIN2DGRIN3BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0705100-B1 | THERAPEUTIC SUBSTITUTED GUANIDINES | CENES LTD (GB) | 2003-07-30 | — | — | EP | claimed |