Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 4/20 | 0.59 |
| ▸ | TAAR1 | Q96RJ0 | 5/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1228231 | 0.83 | IDO1 (0.67) | IDO1TAAR1CYP1A2TSHRCYP2D6 | |
| SCHEMBL18572473 | 0.82 | IDO1 (0.55) | IDO1TAAR1HPGDCYP1A2ALDH1A1 | |
| SCHEMBL18573061 | 0.80 | IDO1 (0.53) | IDO1TAAR1KDM4ECYP1A2MEN1 | |
| SCHEMBL19675835 | 0.78 | TAAR1 (0.39) | IDO1TAAR1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL6928728 | 0.76 | TAAR1 (0.55) | IDO1TAAR1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL3156528 | 0.75 | IDO1 (0.57) | IDO1TAAR1CYP1A2TSHRCYP2D6 | |
| SCHEMBL19535134 | 0.75 | IDO1 (0.57) | IDO1TAAR1KDM4ECYP1A2TSHR | |
| SCHEMBL16343927 | 0.74 | IDO1 (0.61) | IDO1TAAR1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL1520784 | 0.74 | IDO1 (1.00) | IDO1TAAR1CYP3A4 | |
| SCHEMBL30968311 | 0.73 | TSHR (0.62) | IDO1TAAR1KDM4ESMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1027361-B1 | 6,11-BRIDGED ERYTHROMYCIN DERIVATIVES | ABBOTT LAB (US) | 2003-05-07 | — | — | EP | claimed |
| EP-1027361-A1 | 6,11-BRIDGED ERYTHROMYCIN DERIVATIVES | Abbott Laboratories (US) | 2000-08-16 | — | — | EP | claimed |
| US-6046171-A | 6,11-bridged erythromycin derivatives | ABBOTT LABORATORIES (US) | 2000-04-04 | — | — | US | claimed |
| WO-1999021864-A1 | 6,11-BRIDGED ERYTHROMYCIN DERIVATIVES | ABBOTT LABORATORIES (US) | 1999-05-06 | — | — | WO | claimed |
| EP-1027361-B1 | 6,11-BRIDGED ERYTHROMYCIN DERIVATIVES | ABBOTT LAB (US) | 2003-05-07 | — | — | EP | disclosed |
| EP-1027361-A1 | 6,11-BRIDGED ERYTHROMYCIN DERIVATIVES | Abbott Laboratories (US) | 2000-08-16 | — | — | EP | disclosed |
| US-6046171-A | 6,11-bridged erythromycin derivatives | ABBOTT LABORATORIES (US) | 2000-04-04 | — | — | US | disclosed |
| WO-1999021864-A1 | 6,11-BRIDGED ERYTHROMYCIN DERIVATIVES | ABBOTT LABORATORIES (US) | 1999-05-06 | — | — | WO | disclosed |