Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 2/20 | 0.36 |
| ▸ | LSS | P48449 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | THRA | P10827 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7206868 | 1.00 | HPGD (0.52) | HPGDUSP2HSD17B10CNR2SIGMAR1 | |
| SCHEMBL7210592 | 0.99 | HPGD (0.53) | HPGDUSP2HSD17B10CNR2SIGMAR1 | |
| SCHEMBL7210589 | 0.99 | HPGD (0.53) | HPGDUSP2HSD17B10CNR2SIGMAR1 | |
| SCHEMBL4797191 | 0.87 | USP2 (0.49) | HPGDUSP2HSD17B10LSS | |
| SCHEMBL4797182 | 0.87 | USP2 (0.49) | HPGDUSP2HSD17B10LSS | |
| SCHEMBL4803196 | 0.86 | USP2 (0.50) | HPGDUSP2HSD17B10LSS | |
| SCHEMBL4803204 | 0.86 | USP2 (0.50) | HPGDUSP2HSD17B10LSS | |
| SCHEMBL7209029 | 0.85 | HTR2A (0.48) | ALDH1A1LSSHTR2AHTR2C | |
| SCHEMBL7209032 | 0.85 | HTR2A (0.48) | ALDH1A1LSSHTR2AHTR2C | |
| SCHEMBL7208512 | 0.85 | L3MBTL1 (0.37) | HPGDUSP2HSD17B10SIGMAR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1311475-A1 | NOVEL AMINOCYCLOHEXANE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-05-21 | — | — | EP | disclosed |
| WO-2002014267-A1 | NOVEL AMINOCYCLOHEXANE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-02-21 | — | — | WO | disclosed |