Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.51 |
| ▸ | KDR | P35968 | 3/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.50 |
| ▸ | FLT1 | P17948 | 1/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.41 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7211431 | 0.99 | EGFR (0.50) | EGFRKDRFGFR1FLT1PDGFRB | |
| Hydrochloric Acid SCHEMBL4513863 | 0.90 | EGFR (0.48) | EGFRKDRFGFR1FLT1PDGFRB | |
| SCHEMBL7211473 | 0.90 | EGFR (0.49) | EGFRKDRFGFR1FLT1PDGFRB | |
| Hydrochloric Acid SCHEMBL7205616 | 0.89 | EGFR (0.48) | EGFRKDRFGFR1FLT1PDGFRB | |
| Hydrochloric Acid SCHEMBL4518036 | 0.88 | PDGFRB (0.53) | EGFRKDRFGFR1FLT1PDGFRB | |
| SCHEMBL7209903 | 0.85 | TRPA1 (0.49) | EGFRKDRFGFR1FLT1MAPK7 | |
| SCHEMBL5272713 | 0.84 | EGFR (0.48) | EGFRKDRFGFR1FLT1PDGFRB | |
| SCHEMBL4506547 | 0.84 | PDGFRB (0.53) | EGFRKDRFGFR1FLT1PDGFRB | |
| Hydrochloric Acid SCHEMBL7209559 | 0.83 | PDGFRB (0.53) | EGFRKDRFGFR1FLT1PDGFRB | |
| Acetic Acid SCHEMBL4520498 | 0.81 | EGFR (0.43) | EGFRKDRFGFR1FLT1PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0912557-B1 | OXINDOLE DERIVATIVES | ASTRAZENECA AB (SE) | 2003-07-09 | — | — | EP | disclosed |
| US-6265411-B1 | ANGIOGENESIS INHIBITOR | ZENECA LIMITED (GB) | 2001-07-24 | — | — | US | disclosed |
| EP-0912557-A1 | OXINDOLE DERIVATIVES | ZENECA LIMITED (GB) | 1999-05-06 | — | — | EP | disclosed |
| WO-1997042187-A1 | OXINDOLE DERIVATIVES | ZENECA LIMITED (GB) | 1997-11-13 | — | — | WO | disclosed |