Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.65 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | FYN | P06241 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | DTYMK | P23919 | 1/20 | 0.39 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA3 | P07451 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10274092 | 0.85 | MCL1 (0.59) | MCL1LCKFYNHSD17B10TSHR | |
| SCHEMBL2894468 | 0.84 | DTYMK (0.53) | MCL1LCKFYNHSD17B10TSHR | |
| SCHEMBL11723811 | 0.82 | MCL1 (0.71) | MCL1HSD17B10TSHRAKR1C3AKR1C2 | |
| SCHEMBL26664565 | 0.80 | MCL1 (0.46) | MCL1HSD17B10TSHRKMT2AHTT | |
| SCHEMBL2845642 | 0.78 | MCL1 (0.67) | MCL1HSD17B10TSHRAKR1C3AKR1C2 | |
| SCHEMBL3187695 | 0.78 | MCL1 (1.00) | MCL1LCKHSD17B10KMT2AHTT | |
| SCHEMBL10373746 | 0.78 | MCL1 (0.61) | MCL1LCKFYNTSHRKMT2A | |
| SCHEMBL11214673 | 0.77 | MCL1 (0.65) | MCL1HSD17B10TSHRAKR1C3AKR1C2 | |
| SCHEMBL1285810 | 0.77 | MCL1 (0.65) | MCL1HSD17B10TSHRKMT2AHTT | |
| SCHEMBL2823587 | 0.77 | MCL1 (0.65) | MCL1HSD17B10TSHRAKR1C3AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1188121-C | Therapeutic substituted guanidines | CAMBRIDGE NEUROSCIENCE INC (US) | 2005-02-09 | — | — | CN | disclosed |
| EP-0705100-B1 | THERAPEUTIC SUBSTITUTED GUANIDINES | CENES LTD (GB) | 2003-07-30 | — | — | EP | disclosed |
| US-6156741-A | Therapeutic substituted guanidines | CAMBRIDGE NEUROSCIENCE, INC. (US) | 2000-12-05 | — | — | US | disclosed |
| US-6153604-A | Therapeutic substituted guanidines | CAMBRIDGE NEUROSCIENCE, INC. (US) | 2000-11-28 | — | — | US | disclosed |
| US-6147063-A | NEUROTOXICITY | CAMBRIDGE NEUROSCIENCE, INC. (US) | 2000-11-14 | — | — | US | disclosed |
| CN-1126434-A | Therapeutic substituted guanidines | CAMBRIDGE NEUROSCIENCE INC (US) | 1996-07-10 | — | — | CN | disclosed |