Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 12/20 | 0.65 |
| ▸ | PTGS1 | P23219 | 7/20 | 0.55 |
| ▸ | EGFR | P00533 | 2/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6169961 | 0.90 | PTGS2 (0.76) | PTGS2PTGS1EGFRCDK2MEN1 | |
| SCHEMBL27554774 | 0.89 | PTGS2 (0.68) | PTGS2PTGS1EGFR | |
| SCHEMBL27554775 | 0.89 | PTGS2 (0.67) | PTGS2PTGS1EGFRCDK2BCHE | |
| SCHEMBL27533987 | 0.88 | PTGS2 (0.83) | PTGS2PTGS1MEN1KMT2A | |
| SCHEMBL27533827 | 0.86 | PTGS2 (0.60) | PTGS2PTGS1MEN1KMT2A | |
| SCHEMBL27554906 | 0.83 | PTGS2 (0.80) | PTGS2PTGS1EGFRCDK2 | |
| SCHEMBL8113137 | 0.82 | PTGS2 (0.55) | PTGS2PTGS1EGFRCDK2BCHE | |
| SCHEMBL27532185 | 0.81 | PTGS2 (0.61) | PTGS2PTGS1AKR1C3 | |
| SCHEMBL27554509 | 0.80 | PTGS2 (0.58) | PTGS2PTGS1 | |
| SCHEMBL6168900 | 0.79 | PTGS2 (1.00) | PTGS2PTGS1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1284064-A | 2,3-substituted indole compounds as cox-2 inhibitors | PFIZER PHARMA (US) | 2001-02-14 | — | — | CN | claimed |
| US-6608070-B1 | Useful for treatment of medical condition in which prostaglandins are implicated as pathogens | NAKAO KAZUNARI (JP) | 2003-08-19 | — | — | US | disclosed |
| CN-1284064-A | 2,3-substituted indole compounds as cox-2 inhibitors | PFIZER PHARMA (US) | 2001-02-14 | — | — | CN | disclosed |