Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 19/20 | 0.70 |
| ▸ | ADORA3 | P0DMS8 | 15/20 | 0.69 |
| ▸ | ADORA2B | P29275 | 8/20 | 0.69 |
| ▸ | ADORA1 | P30542 | 7/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7203736 | 0.91 | ADORA2A (0.69) | ADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL7567108 | 0.90 | ADORA2A (0.57) | ADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL7587828 | 0.81 | ADORA2A (0.57) | ADORA2AADORA3ADORA2BADORA1 | |
| Gw-328267 SCHEMBL1979140 | 0.81 | ADORA2A (1.00) | ADORA2AADORA3ADORA2BADORA1 | |
| Gw-328267 SCHEMBL1983128 | 0.81 | ADORA2A (1.00) | ADORA2AADORA3ADORA2BADORA1 | |
| Gw-328267 SCHEMBL1980933 | 0.81 | ADORA2A (1.00) | ADORA2AADORA3ADORA2BADORA1 | |
| Gw-328267 SCHEMBL13268494 | 0.81 | ADORA2A (1.00) | ADORA2AADORA3ADORA2BADORA1 | |
| Gw-328267 SCHEMBL1983126 | 0.81 | ADORA2A (1.00) | ADORA2AADORA3ADORA2BADORA1 | |
| Gw-328267 SCHEMBL13268529 | 0.81 | ADORA2A (1.00) | ADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL7207964 | 0.81 | ADORA2A (0.57) | ADORA2AADORA3ADORA2BADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6610665-B1 | Treatment of inflammatory diseases, asthma or chronic obstructive pulmonary disease | SMITHKLINE BEECHAM CORPORATION | 2003-08-26 | — | — | US | claimed |
| EP-1056759-B1 | 2-(PURIN-9-YL) -TETRAHYDROFURAN-3, 4-DIOL DERIVATIVES | GLAXO GROUP LTD (GB) | 2002-09-04 | — | — | EP | claimed |
| WO-2002036816-A2 | METHOD OF DETERMINING SUSCEPTIBILITY TO DISEASES | GLAXO GROUP LIMITED (GB) | 2002-05-10 | — | — | WO | disclosed |