Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 7/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4064122 | 0.81 | MC4R (0.56) | MC4RKCNH2KMT2A | |
| SCHEMBL4008428 | 0.79 | MC4R (0.63) | MC4RKCNH2KMT2A | |
| SCHEMBL4824573 | 0.77 | KMT2A (0.43) | MC4RKCNH2KDM4ETDP1MEN1 | |
| SCHEMBL4160348 | 0.76 | SLC6A4 (0.55) | KDM4EMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL4147932 | 0.75 | MC4R (0.53) | MC4RKCNH2KDM4ETDP1MEN1 | |
| SCHEMBL4364071 | 0.75 | MC4R (0.42) | MC4RKCNH2KDM4EMEN1KMT2A | |
| SCHEMBL4357248 | 0.75 | MC4R (0.42) | MC4RKCNH2KDM4ETDP1MEN1 | |
| SCHEMBL4359218 | 0.74 | DRD2 (0.49) | MC4RKCNH2 | |
| SCHEMBL4823936 | 0.74 | KDM4E (0.47) | MC4RKDM4ETDP1MEN1KMT2A | |
| SCHEMBL4146963 | 0.73 | MC4R (0.45) | MC4RKCNH2KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1363890-A2 | MELANOCORTIN-4 RECEPTOR BINDING COMPOUNDS AND METHODS OF USE THEREOF | Millennium Pharmaceuticals, Inc. (US) | 2003-11-26 | — | — | EP | disclosed |
| WO-2002062766-A2 | MELANOCORTIN-4 RECEPTOR BINDING COMPOUNDS AND METHODS OF USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-08-15 | — | — | WO | disclosed |