Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7207672 | 0.74 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4DEPHX2 | |
| SCHEMBL14785026 | 0.65 | HSP90AB1 (0.53) | — | |
| SCHEMBL15590810 | 0.64 | NPC1 (0.53) | EPHX2 | |
| SCHEMBL18323761 | 0.64 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL11656204 | 0.64 | MEN1 (0.41) | GABRA1GABRB2L3MBTL1 | |
| SCHEMBL6245720 | 0.64 | MEN1 (0.49) | — | |
| SCHEMBL5280798 | 0.63 | EPHX2 (0.47) | GABRA1GABRB2EPHX2 | |
| SCHEMBL12231465 | 0.63 | HSP90AB1 (0.54) | — | |
| SCHEMBL16840172 | 0.63 | ERCC1 (0.38) | PDE4APDE4BPDE4CPDE4DGABRA1 | |
| SCHEMBL27557452 | 0.62 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4DEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0841913-B1 | USE OF SULFAMIC ACID DERIVATIVES, ACYL SULFONAMIDES OR SULFONYL CARBAMATES FOR THE MANUFACTURE OF A MEDICAMENT FOR LOWERING LIPOPROTEIN LEVELS | WARNER LAMBERT CO (US) | 2003-02-05 | — | — | EP | claimed |