Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 3/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7207668 | 0.74 | PDE4A (0.37) | PDE4APDE4BPDE4CPDE4DEPHX2 | |
| SCHEMBL17041598 | 0.72 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL27557452 | 0.69 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL2437519 | 0.69 | NPC1 (0.51) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL2439507 | 0.69 | NPC1 (0.51) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL2438485 | 0.68 | EPHX2 (0.57) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL1278317 | 0.68 | EPHX2 (0.57) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL28595923 | 0.68 | EPHX2 (0.57) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL7094216 | 0.68 | EPHX2 (0.57) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL29171624 | 0.68 | PTPN1 (0.54) | PDE4APDE4BPDE4CPDE4DNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0841913-B1 | USE OF SULFAMIC ACID DERIVATIVES, ACYL SULFONAMIDES OR SULFONYL CARBAMATES FOR THE MANUFACTURE OF A MEDICAMENT FOR LOWERING LIPOPROTEIN LEVELS | WARNER LAMBERT CO (US) | 2003-02-05 | — | — | EP | claimed |