SCHEMBL7207939

SCHEMBL7207939

COCCCn1c(=O)c2c(CBr)c(-c3ccc(OC)cc3)sc2n(Cc2ccccc2F)c1=O

nearest known ligand 0.52

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GNRHR P30968 17/20 0.52
ADORA2B P29275 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7208411 0.89 ADORA2B (0.53) GNRHRADORA2B
SCHEMBL7206328 0.87 GNRHR (0.72) GNRHR
SCHEMBL7597266 0.72 GNRHR (0.42) GNRHR
SCHEMBL7012637 0.72 GNRHR (0.62) GNRHR
SCHEMBL7203152 0.71 GNRHR (0.48) GNRHR
SCHEMBL7595933 0.71 GNRHR (0.54) GNRHR
Hydrochloric Acid SCHEMBL7203755 0.71 GNRHR (0.85) GNRHR
Hydrochloric Acid SCHEMBL7748993 0.70 GNRHR (0.62) GNRHR
SCHEMBL7855497 0.69 GNRHR (0.45) GNRHR
SCHEMBL8159145 0.69 GNRHR (0.49) GNRHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0808317-B1 THIENOPYRIMIDINE DERIVATIVES, THEIR PRODUCTION AND USE TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2003-09-10 EP disclosed
US-6180792-B1 DRUGS, ANTISECRETORY AGENTS AND HORMONE INHIBITORS FOR LH-RH TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2001-01-30 US disclosed
US-6048863-A SEXUAL DISORDERS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2000-04-11 US disclosed
US-6015789-A LUTEINIZING HORMONE RELEASING HORMONE AGONIST AND A LUTEINIZING HORMONE RELEASING HORMONE ANTAGONIST IN COMBINATION, TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2000-01-18 US disclosed
US-5977132-A GALACTORRHEA, HYPERPROLACTINEMIC OVULATION, PROLACTINOMA AND BRAIN TUMORS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1999-11-02 US disclosed
EP-0781774-A2 Prolactin production inhibitory agents TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1997-07-02 EP disclosed