Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 4/20 | 0.57 |
| ▸ | XDH | P47989 | 1/20 | 0.54 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.50 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5839047 | 0.88 | BRAF (0.75) | BRAFTNNI3K | |
| SCHEMBL5839589 | 0.80 | BRAF (0.57) | BRAFXDHTNNI3K | |
| SCHEMBL4924939 | 0.80 | MKNK1 (0.59) | BRAFTNNI3K | |
| SCHEMBL5840446 | 0.77 | MKNK1 (0.63) | BRAFXDHTNNI3KEIF2AK2 | |
| SCHEMBL3001381 | 0.76 | TNNI3K (0.61) | BRAFXDHTNNI3K | |
| SCHEMBL2995235 | 0.75 | BRAF (0.73) | BRAFXDHTNNI3K | |
| SCHEMBL3001570 | 0.75 | BRAF (0.77) | BRAFXDHTNNI3KTMIGD3HTR2C | |
| SCHEMBL5841027 | 0.74 | BRAF (0.74) | BRAFXDHTNNI3K | |
| SCHEMBL2996504 | 0.74 | XDH (0.57) | BRAFXDHTNNI3K | |
| SCHEMBL2995191 | 0.73 | BRAF (0.75) | BRAFXDHTNNI3K |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0874846-B1 | PURINE DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | NOVARTIS AG (CH) | 2003-04-02 | — | — | EP | disclosed |
| CN-1066147-C | Purine derivatives and process for preparing same | 诺瓦提斯公司 | 2001-05-23 | — | — | CN | disclosed |
| CN-1202896-A | Purine derivatives and processes for their preparation | 诺瓦提斯公司 | 1998-12-23 | — | — | CN | disclosed |
| EP-0874846-A1 | PURINE DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | Novartis AG (CH) | 1998-11-04 | — | — | EP | disclosed |
| WO-1997016452-A1 | PURINE DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | NOVARTIS AG (CH) | 1997-05-09 | — | — | WO | disclosed |