Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | PRNP | P04156 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7209583 | 0.77 | ALDH1A1 (0.54) | PDE4AALDH1A1KMT2AKDM4EMAPT | |
| SCHEMBL9870226 | 0.71 | PDE4A (0.52) | PDE4AALDH1A1PDE4BPDE4CPDE4D | |
| SCHEMBL25374055 | 0.70 | PDE4A (0.56) | PDE4AALDH1A1PDE4BPDE4CPDE4D | |
| SCHEMBL30368356 | 0.70 | PDE4A (0.56) | PDE4AALDH1A1PDE4BPDE4CPDE4D | |
| SCHEMBL2039633 | 0.68 | PDE4A (0.50) | PDE4AALDH1A1PDE4BPDE4CPDE4D | |
| SCHEMBL1822961 | 0.68 | PDE4A (0.50) | PDE4AALDH1A1PDE4BPDE4CPDE4D | |
| SCHEMBL30555650 | 0.67 | CYP19A1 (0.38) | ALDH1A1TP53L3MBTL1 | |
| SCHEMBL8270926 | 0.67 | PDE4A (0.49) | PDE4AALDH1A1PDE4BPDE4CPDE4D | |
| SCHEMBL2041759 | 0.67 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL5322466 | 0.67 | PDE4A (0.87) | PDE4AALDH1A1PDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882021-B1 | NEW PHENANTHRIDINES | ALTANA PHARMA AG (DE) | 2003-03-05 | — | — | EP | disclosed |
| US-6191138-B1 | THERAPY FOR RESPIRATORY SYSTEM DISORDERS | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 2001-02-20 | — | — | US | disclosed |
| EP-0882021-A1 | NEW PHENANTHRIDINES | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1998-12-09 | — | — | EP | disclosed |
| WO-1997028131-A1 | NEW PHENANTHRIDINES | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1997-08-07 | — | — | WO | disclosed |