Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 7/20 | 0.65 |
| ▸ | ADAMTS7 | Q9UKP4 | 5/20 | 0.65 |
| ▸ | MMP1 | P03956 | 10/20 | 0.52 |
| ▸ | MMP13 | P45452 | 9/20 | 0.52 |
| ▸ | ADAMTS4 | O75173 | 3/20 | 0.51 |
| ▸ | MMP2 | P08253 | 3/20 | 0.51 |
| ▸ | MMP14 | P50281 | 2/20 | 0.51 |
| ▸ | ADAM17 | P78536 | 6/20 | 0.48 |
| ▸ | ADAMTS1 | Q9UHI8 | 2/20 | 0.48 |
| ▸ | TNF | P01375 | 1/20 | 0.48 |
| ▸ | MMP3 | P08254 | 1/20 | 0.48 |
| ▸ | MMP9 | P14780 | 1/20 | 0.48 |
| ▸ | MMP8 | P22894 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7214278 | 0.95 | ADAMTS5 (0.61) | ADAMTS5ADAMTS7MMP1MMP13ADAMTS4 | |
| SCHEMBL7213014 | 0.92 | ADAMTS5 (0.65) | ADAMTS5ADAMTS7MMP1MMP13ADAMTS4 | |
| SCHEMBL7214317 | 0.91 | ADAMTS5 (0.57) | ADAMTS5ADAMTS7MMP1MMP13ADAMTS4 | |
| SCHEMBL7207007 | 0.88 | ADAMTS5 (0.60) | ADAMTS5ADAMTS7MMP1MMP13ADAMTS4 | |
| SCHEMBL7208115 | 0.86 | ADAMTS5 (0.61) | ADAMTS5ADAMTS7MMP1MMP13ADAMTS4 | |
| SCHEMBL7208131 | 0.84 | ADAMTS5 (0.58) | ADAMTS5ADAMTS7MMP1MMP13ADAMTS4 | |
| SCHEMBL7213000 | 0.82 | ADAMTS5 (0.66) | ADAMTS5ADAMTS7MMP1MMP13ADAMTS4 | |
| SCHEMBL7208597 | 0.81 | ADAMTS5 (0.61) | ADAMTS5ADAMTS7MMP1MMP13ADAMTS4 | |
| SCHEMBL7208610 | 0.80 | ADAMTS5 (0.63) | ADAMTS5ADAMTS7MMP1MMP13ADAMTS4 | |
| SCHEMBL7214222 | 0.80 | ADAMTS5 (0.65) | ADAMTS5ADAMTS7MMP1MMP13ADAMTS4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1181286-B1 | 3-(ARYLSULFONYLAMINO)-TETRAHYDROPYRAN-3-CARBOXYLIC ACID HYDROXAMIDES | PFIZER PROD INC (US) | 2003-11-12 | — | — | EP | disclosed |
| EP-1181286-A1 | 3-(ARYLSULFONYLAMINO)-TETRAHYDROPYRAN-3-CARBOXYLIC ACID HYDROXAMIDES | Pfizer Products Inc. (US) | 2002-02-27 | — | — | EP | disclosed |
| US-6197810-B1 | ANTIARTHRITIC AGENTS; ANTICANCE RAGENTS; ANTIINFLAMMATORY AGENTS | PFIZER INC | 2001-03-06 | — | — | US | disclosed |
| WO-2000073295-A1 | 3-(ARYLSULFONYLAMINO)-TETRAHYDROPYRAN-3-CARBOXYLIC ACID HYDROXAMIDES | PFIZER PRODUCTS INC. (US) | 2000-12-07 | — | — | WO | disclosed |