Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 10/20 | 0.73 |
| ▸ | CDK5 | Q00535 | 11/20 | 0.60 |
| ▸ | CDK5R1 | Q15078 | 10/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | CCNA2 | P20248 | 10/20 | 0.55 |
| ▸ | CDK2 | P24941 | 10/20 | 0.55 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.55 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.55 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.55 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.55 |
| ▸ | CDK7 | P50613 | 1/20 | 0.55 |
| ▸ | CDK9 | P50750 | 1/20 | 0.55 |
| ▸ | CCNH | P51946 | 1/20 | 0.55 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.55 |
| ▸ | GSK3B | P49841 | 1/20 | 0.55 |
| ▸ | CCNA1 | P78396 | 9/20 | 0.54 |
| ▸ | DYRK1A | Q13627 | 8/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5840807 | 1.00 | CDK1 (0.73) | CDK1CDK5CDK5R1KDM4ENPC1 | |
| SCHEMBL5841668 | 0.87 | CDK5 (0.78) | CDK1CDK5CDK5R1KDM4ENPC1 | |
| SCHEMBL8710243 | 0.87 | CDK5 (0.78) | CDK1CDK5CDK5R1KDM4ENPC1 | |
| SCHEMBL5841752 | 0.87 | CDK1 (0.72) | CDK1CDK5CDK5R1KDM4ENPC1 | |
| SCHEMBL5841742 | 0.87 | CDK1 (0.72) | CDK1CDK5CDK5R1KDM4ENPC1 | |
| SCHEMBL8706894 | 0.87 | CDK5 (0.78) | CDK1CDK5CDK5R1KDM4ENPC1 | |
| SCHEMBL5839851 | 0.85 | CDK1 (0.67) | CDK1CDK5CDK5R1KDM4ENPC1 | |
| SCHEMBL5839860 | 0.85 | CDK1 (0.67) | CDK1CDK5CDK5R1KDM4ENPC1 | |
| SCHEMBL5839334 | 0.85 | CDK1 (0.68) | CDK1CDK5CDK5R1KDM4ENPC1 | |
| SCHEMBL5839344 | 0.85 | CDK1 (0.68) | CDK1CDK5CDK5R1KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0874846-B1 | PURINE DERIVATIVES AND PROCESSES FOR THEIR PREPARATION | NOVARTIS AG (CH) | 2003-04-02 | — | — | EP | disclosed |