SCHEMBL7208719

SCHEMBL7208719

CN1C(=O)[C@H](NC(=O)CCc2cccc(C#N)c2)N=C(c2ccccc2)c2ccccc21

nearest known ligand 0.69

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CCKBR P32239 10/20 0.69
HDAC3 O15379 5/20 0.63
HDAC4 P56524 5/20 0.63
HDAC1 Q13547 5/20 0.63
HDAC7 Q8WUI4 5/20 0.63
HDAC2 Q92769 5/20 0.63
HDAC10 Q969S8 5/20 0.63
HDAC11 Q96DB2 5/20 0.63
HDAC8 Q9BY41 5/20 0.63
HDAC6 Q9UBN7 5/20 0.63
HDAC9 Q9UKV0 5/20 0.63
HDAC5 Q9UQL6 5/20 0.63
KCNH2 Q12809 2/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8611964 1.00 CCKBR (0.69) CCKBRHDAC3HDAC4HDAC1HDAC7
SCHEMBL8611256 0.90 HDAC3 (0.66) CCKBRHDAC3HDAC4HDAC1HDAC7
SCHEMBL8611261 0.90 HDAC3 (0.66) CCKBRHDAC3HDAC4HDAC1HDAC7
SCHEMBL8608841 0.88 HDAC3 (0.76) CCKBRHDAC3HDAC4HDAC1HDAC7
SCHEMBL7170310 0.88 HDAC3 (0.76) CCKBRHDAC3HDAC4HDAC1HDAC7
SCHEMBL8612743 0.87 CCKBR (0.67) CCKBRHDAC3HDAC4HDAC1HDAC7
SCHEMBL8612748 0.87 CCKBR (0.67) CCKBRHDAC3HDAC4HDAC1HDAC7
SCHEMBL8927406 0.84 CCKBR (0.69) CCKBRHDAC3HDAC4HDAC1HDAC7
SCHEMBL8609751 0.84 CCKBR (0.69) CCKBRHDAC3HDAC4HDAC1HDAC7
SCHEMBL7167124 0.82 HDAC3 (0.80) CCKBRHDAC3HDAC4HDAC1HDAC7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0907644-A4 PHARMACEUTICAL PREPARATION MERCK & CO INC (US) 2003-02-05 EP disclosed
EP-0907644-A1 PHARMACEUTICAL PREPARATION Merck & Co., Inc. (US) 1999-04-14 EP disclosed
US-5817658-A ADMINISTERING A DIAZEPINE COMPOUND; DISEASES OF THE EAR MERCK & COMPANY, INC. (US) 1998-10-06 US disclosed
US-5776930-A CARDIOVASCULAR DISORDERS MERCK & COMPANY, INC. (US) 1998-07-07 US disclosed
WO-1998000405-A1 PHARMACEUTICAL PREPARATION MERCK & CO., INC. (US) 1998-01-08 WO disclosed
CN-1142184-A Antiarrhythmic benzodiazepines * MERCK & CO INC (US) 1997-02-05 CN disclosed
US-5597818-A CARDIOVASCULAR DISORDERS MERCK & CO., INC. (US) 1997-01-28 US disclosed
US-5595990-A TREATMENT OF CARDIOVASCULAR DISORDERS MERCK & CO., INC. (US) 1997-01-21 US disclosed
US-5428031-A Benzodiazepine analogs; cardiovascular disorders MERCK & CO., INC. (US) 1995-06-27 US disclosed
US-5426185-A Antiarrhythmia agents having reduced side effects MERCK & CO., INC. (US) 1995-06-20 US disclosed
WO-1995014471-A1 ANTIARRHYTHMIC BENZODIAZEPINES MERCK & CO., INC. (US) 1995-06-01 WO disclosed