SCHEMBL7208745

SCHEMBL7208745

C[C@H]1O[C@@H](n2cc(I)c(NC(=O)OCC3CCCC3)nc2=O)[C@H](O)[C@@H]1O

nearest known ligand 0.55

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.55
ADK P55263 15/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8184925 1.00 LMNA (0.55) LMNAADK
SCHEMBL7209492 0.98 LMNA (0.55) LMNAADK
SCHEMBL8184942 0.98 LMNA (0.55) LMNAADK
SCHEMBL7204507 0.96 LMNA (0.57) LMNAADK
SCHEMBL8193382 0.96 LMNA (0.57) LMNAADK
SCHEMBL284985 0.88 LMNA (0.69) LMNAADK
SCHEMBL284984 0.88 LMNA (0.69) LMNAADK
SCHEMBL8192424 0.86 LMNA (0.53) LMNAADK
SCHEMBL7205865 0.86 LMNA (0.53) LMNAADK
SCHEMBL8192416 0.86 LMNA (0.53) LMNAADK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1060183-B1 5'-DEOXYCYTIDINE DERIVATIVES HOFFMANN LA ROCHE (CH) 2003-04-23 EP claimed
EP-1060183-A1 5'-DEOXYCYTIDINE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2000-12-20 EP claimed
WO-1999040099-A1 5'-DEOXYCYTIDINE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 1999-08-12 WO claimed
EP-1060183-B1 5'-DEOXYCYTIDINE DERIVATIVES HOFFMANN LA ROCHE (CH) 2003-04-23 EP disclosed
EP-1060183-A1 5'-DEOXYCYTIDINE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2000-12-20 EP disclosed
WO-1999040099-A1 5'-DEOXYCYTIDINE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 1999-08-12 WO disclosed