Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 2/20 | 0.36 |
| ▸ | BLM | P54132 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.36 |
| ▸ | GABRP | O00591 | 1/20 | 0.36 |
| ▸ | GABRD | O14764 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrazine SCHEMBL28251779 | 0.84 | TSHR (0.45) | TSHRALDH1A1HSD17B10TDP1 | |
| SCHEMBL209234 | 0.83 | — | — | |
| SCHEMBL3861871 | 0.71 | PAOX (0.48) | TDP1KMT2AMEN1PAOX | |
| SCHEMBL27344240 | 0.70 | TSHR (0.38) | TSHRALDH1A1HSD17B10TDP1LMNA | |
| SCHEMBL1899004 | 0.69 | TSHR (0.40) | TSHRALDH1A1HSD17B10TDP1 | |
| Propane SCHEMBL2296352 | 0.68 | TSHR (0.36) | TSHRALDH1A1HSD17B10TDP1 | |
| SCHEMBL11121471 | 0.68 | TSHR (0.41) | TSHRALDH1A1HSD17B10TDP1 | |
| Butylamine SCHEMBL3926203 | 0.68 | DNM1 (0.37) | TSHRALDH1A1LMNACYP1A2THRB | |
| SCHEMBL22733774 | 0.67 | TSHR (0.39) | TSHRALDH1A1HSD17B10TDP1 | |
| Acetic Acid SCHEMBL4397846 | 0.67 | CYP1A2 (0.53) | TSHRALDH1A1LMNACYP1A2THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1000072-B1 | PROCESS FOR THE PREPARATION OF [2-((8,9)- DIOXO-2,6-DIAZABICYCLO [5.2.0]-NON-1(7)-EN-2-YL)-ETHYL] PHOSPHONIC ACID | WYETH CORP (US) | 2003-02-19 | — | — | EP | disclosed |
| EP-1000072-A1 | PROCESS FOR THE PREPARATION OF 2-((8,9)- DIOXO-2,6-DIAZABICYCLO 5.2.0]-NON-1(7)-EN-2-YL)-ETHYL] PHOSPHONIC ACID | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-05-17 | — | — | EP | disclosed |
| US-6011168-A | Process for the preparation[2-((8,9)-dioxo-2,6-diazabicyclo[5.2.0]-non-1(7)-en-2-yl)ethy l]phosphonic acid | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-01-04 | — | — | US | disclosed |
| US-5990307-A | Process for the preparation of [2-((8.9)-Dioxo-2,6-Diazabicyclo [5.2.0]-Non-1(7)-en-2yl) Ethyl]Phosphonic acid | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-11-23 | — | — | US | disclosed |
| WO-1999006417-A1 | PROCESS FOR THE PREPARATION OF [2-((8,9)- DIOXO-2,6-DIAZABICYCLO [5.2.0]-NON-1(7)-EN-2-YL)-ETHYL] PHOSPHONIC ACID | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-02-11 | — | — | WO | disclosed |