Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5221988 | 0.90 | CHRM2 (0.50) | L3MBTL1CYP3A4CYP2C19POLBALDH1A1 | |
| SCHEMBL16915160 | 0.77 | RET (0.38) | POLBALDH1A1MEN1KMT2AGAA | |
| SCHEMBL28041845 | 0.76 | CYP2D6 (0.40) | CYP3A4CYP2C19ALDH1A1CHRM2CHRM4 | |
| SCHEMBL6580284 | 0.76 | CYP3A4 (0.47) | L3MBTL1CYP3A4CYP2C19NPC1RAB9A | |
| SCHEMBL23886508 | 0.74 | CYP3A4 (0.60) | CYP3A4CYP2C19ALDH1A1MEN1KMT2A | |
| SCHEMBL20536090 | 0.74 | CYP2D6 (0.54) | L3MBTL1CYP3A4CYP2C19ALDH1A1CHRM2 | |
| SCHEMBL14200160 | 0.73 | PSEN1 (0.33) | ALDH1A1CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL11035416 | 0.73 | CHRM2 (0.50) | L3MBTL1NPC1RAB9APOLBCHRM2 | |
| SCHEMBL23904643 | 0.71 | CYP3A4 (0.60) | L3MBTL1CYP3A4CYP2C19NPC1RAB9A | |
| SCHEMBL5228029 | 0.71 | CHRM2 (0.48) | NPC1RAB9APOLBCHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1251846-A4 | C-4 CARBONATE TAXANES | BRISTOL MYERS SQUIBB CO (US) | 2003-03-12 | — | — | EP | disclosed |
| EP-1251846-A1 | C-4 CARBONATE TAXANES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-10-30 | — | — | EP | disclosed |
| WO-2001056565-A1 | C-4 CARBONATE TAXANES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-08-09 | — | — | WO | disclosed |