Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 8/20 | 0.55 |
| ▸ | ADORA2A | P29274 | 7/20 | 0.55 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.55 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.55 |
| ▸ | NT5E | P21589 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7211345 | 0.90 | ADORA2A (0.54) | ADORA3ADORA2AADORA1ADORA2BNT5E | |
| SCHEMBL7206352 | 0.90 | ADORA2A (0.55) | ADORA3ADORA2AADORA1ADORA2BNT5E | |
| SCHEMBL7208372 | 0.86 | ADORA3 (0.49) | ADORA3ADORA2AADORA1ADORA2BNT5E | |
| SCHEMBL7106547 | 0.84 | ADORA3 (0.54) | ADORA3ADORA2AADORA1ADORA2BNT5E | |
| SCHEMBL7100132 | 0.84 | ADORA3 (0.54) | ADORA3ADORA2AADORA1ADORA2BNT5E | |
| SCHEMBL2806951 | 0.83 | ADORA3 (0.53) | ADORA3ADORA2AADORA1ADORA2B | |
| SCHEMBL7208637 | 0.83 | ADORA3 (0.57) | ADORA3ADORA2AADORA1ADORA2BNT5E | |
| SCHEMBL7098846 | 0.83 | ADORA3 (0.58) | ADORA3ADORA2AADORA1ADORA2BNT5E | |
| SCHEMBL8325836 | 0.83 | ADORA2A (0.75) | ADORA3ADORA2AADORA1ADORA2B | |
| SCHEMBL1415112 | 0.83 | ADORA2A (0.75) | ADORA3ADORA2AADORA1ADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6610665-B1 | Treatment of inflammatory diseases, asthma or chronic obstructive pulmonary disease | SMITHKLINE BEECHAM CORPORATION | 2003-08-26 | — | — | US | disclosed |
| EP-1056759-B1 | 2-(PURIN-9-YL) -TETRAHYDROFURAN-3, 4-DIOL DERIVATIVES | GLAXO GROUP LTD (GB) | 2002-09-04 | — | — | EP | disclosed |