Sugi Predict

Sugi Predict / Compounds / SCHEMBL7209481

SCHEMBL7209481

SCHEMBL7209481

O=c1cc(-c2cccc(Cl)c2)c2cc(-c3ccc(Cl)cc3)cc3c2n1CCO3

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ FNTA P49354 13/20 0.59
▸ FNTB P49356 13/20 0.59
▸ PGGT1B P53609 1/20 0.43
▸ CA12 O43570 1/20 0.34
▸ CA9 Q16790 1/20 0.34
▸ PIK3CA P42336 1/20 0.34
▸ PIK3CB P42338 1/20 0.34
▸ PIK3CG P48736 1/20 0.34
▸ KDM4E B2RXH2 1/20 0.33
▸ NPC1 O15118 1/20 0.33
▸ ALDH1A1 P00352 1/20 0.33
▸ LMNA P02545 1/20 0.33
▸ TP53 P04637 1/20 0.33
▸ MAPT P10636 1/20 0.33
▸ HPGD P15428 1/20 0.33
▸ RAB9A P51151 1/20 0.33
▸ SMN1; SMN2 Q16637 1/20 0.33
▸ NPSR1 Q6W5P4 1/20 0.33
▸ TDP2 O95551 1/20 0.33
▸ PGR P06401 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7207710 0.85 FNTA (0.55) FNTAFNTBPGGT1BCA12CA9
SCHEMBL7207696 0.84 FNTA (0.56) FNTAFNTBPGGT1BCA12CA9
SCHEMBL4432840 0.74 FNTA (0.56) FNTAFNTBPGGT1BCA12CA9
SCHEMBL7209530 0.74 FNTA (0.53) FNTAFNTBPGGT1BCA12CA9
SCHEMBL29445867 0.69 FNTA (0.53) FNTAFNTBPGGT1BKDM4EALDH1A1
SCHEMBL25257140 0.68 MCL1 (0.49) FNTAFNTBPIK3CAPIK3CBPIK3CG
SCHEMBL31280287 0.68 MCL1 (0.49) FNTAFNTBPIK3CAPIK3CBPIK3CG
SCHEMBL4426275 0.68 FNTA (0.55) FNTAFNTBPGGT1BCA12CA9
SCHEMBL7208658 0.68 FNTA (0.56) FNTAFNTBPGGT1BKDM4EALDH1A1
SCHEMBL7210122 0.67 FNTA (0.54) FNTAFNTBPGGT1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0970079-B1 FARNESYL TRANSFERASE INHIBITING 1,8-ANNELATED QUINOLINONE DERIVATIVES SUBSTITUTED WITH N- OR C-LINKED IMIDAZOLES JANSSEN PHARMACEUTICA NV (BE) 2003-10-01 — — EP disclosed
US-6444812-B1 SUCH AS 7-(3-CHLOROPHENYL)-9-((4-CHLOROPHENYL)-1H-IMIDAZOL-1-YLMETHYL)-2,3-DIHYDRO -1H,5H-BENZO(IJ) QUINOLIZIN-5-ONE; FOR FORMING ONCOGENES FOR SIGNALLING TRANSFORMATION OF TUMOR CELLS JANSSEN PHARMACEUTICA N.V. (BE) 2002-09-03 — — US disclosed
US-20020049327-A1 Farnesyl transferase inhibiting 1,8-annelated quinolinone derivatives substituted with N- or C-linked imidazoles VENET MARC GASTON (FR) 2002-04-25 — — US disclosed
US-6187786-B1 ANTITUMOR AND ANTICARCINOGENIC AGENTS JANSSEN PHARMACEUTICA N.V. (BE) 2001-02-13 — — US disclosed
EP-0970079-A1 FARNESYL TRANSFERASE INHIBITING 1,8-ANNELATED QUINOLINONE DERIVATIVES SUBSTITUTED WITH N- OR C-LINKED IMIDAZOLES JANSSEN PHARMACEUTICA N.V. (BE) 2000-01-12 — — EP disclosed
WO-1998040383-A1 FARNESYL TRANSFERASE INHIBITING 1,8-ANNELATED QUINOLINONE DERIVATIVES SUBSTITUTED WITH N- OR C-LINKED IMIDAZOLES JANSSEN PHARMACEUTICA N.V. (BE) 1998-09-17 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020049327-A1 Farnesyl transferase inhibiting 1,8-annelated quinolinone derivatives substituted with N- or C-linked imidazoles HCCS, CYP7A1, DHCR7 FNTA 4/4885FNTB 5/4885PGGT1B 142/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.